Using low-temperature thermochronology on apatite and zircon crystals, we show that the western Reguibat Shield, located in the northern part of the West African Craton, experienced significant cooling and heating events between Jurassic and present times. The obtained apatite fission track ages range between 49 and 102 Ma with mean track lengths varying between 11.6 and 13.3 μm and Dpar values between 1.69 and 3.08 μm. Zircon fission track analysis yielded two ages of 159 and 118 Ma. Apatite (U–Th)/He uncorrected single-grain ages range between 76 and 95 Ma. Thermal inverse modelling indicates that the Reguibat Shield was exhumed during the Early Cretaceous, Late Cretaceous, Palaeocene–Eocene and Quaternary. These exhumation events were coeval with regional tectonic and geodynamic events, and were probably driven by a combined effect of plate tectonics and mantle dynamics.