Metal-Organic Framework Capillary Microreactor for Application in Click Chemistry

Lara A. Truter, J. Juan Alcañiz, Freek Kapteijn, Tjeerd A. Nijhuis, J. Gascon, Jaap C. Schouten

Research output: Contribution to journalArticleScientificpeer-review

6 Citations (Scopus)

Abstract

A Cu/PMA-MIL-101(Cr) metal-organic-framework-coated microreactor has been applied in the 1,3-dipolar cycloaddition of benzyl azide and phenylactetylene (click chemistry). The Cu/PMA-MIL-101(Cr) catalyst was incorporated by using a washcoating method. The use of tetraethylorthosilicate (TEOS) and a copolymer pluronic F127 as binders resulted in a stable and uniform coating of 6 μm. The application of the Cu/PMA-MIL-101(Cr) capillary microreactor in the click-chemistry reaction resulted in a similar intrinsic activity as in the batch reactor, and a continuous production for more than 150 h time-on-stream could be achieved. The presence of water in the reagent feed led to reversible catalyst deactivation and was necessary to be removed to obtain a stable catalyst operation.

Original languageEnglish
Pages (from-to)1692-1698
Number of pages7
JournalChemCatChem
Volume8
Issue number9
DOIs
Publication statusPublished - 9 May 2016

Keywords

  • click chemistry
  • copper
  • mesoporous materials
  • metal-organic frameworks
  • microreactors

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