Metals in Biotechnology: Cr-Driven Stereoselective Reduction of Conjugated C=C Double Bonds

Marine C.R. Rauch; Yann Gallou; Léna Delorme; Caroline E. Paul; Isabel W.C.E. Arends; Frank Hollmann

doi:10.1002/cbic.201900685

Metals in Biotechnology: Cr-Driven Stereoselective Reduction of Conjugated C=C Double Bonds

Marine C.R. Rauch, Yann Gallou, Léna Delorme, Caroline E. Paul, Isabel W.C.E. Arends, Frank Hollmann^*

^*Corresponding author for this work

BT/Biocatalysis

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

Elemental metals are shown to be suitable sacrificial electron donors to drive the stereoselective reduction of conjugated C=C double bonds using Old Yellow Enzymes as catalysts. Both direct electron transfer from the metal to the enzyme as well as mediated electron transfer is feasible, although the latter excels by higher reaction rates. The general applicability of this new chemoenzymatic reduction method is demonstrated, and current limitations are outlined.

Original language	English
Pages (from-to)	1112-1115
Number of pages	4
Journal	ChemBioChem
Volume	21
Issue number	8
DOIs	https://doi.org/10.1002/cbic.201900685
Publication status	Published - 2019

Keywords

conjugated double bonds
direct regeneration
metals
old yellow enzymes
stereoselective reduction

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10.1002/cbic.201900685

Rauch_et_al-2019-ChemBioChemFinal published version, 597 KBLicence: CC BY

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AU - Delorme, Léna

AU - Paul, Caroline E.

AU - Arends, Isabel W.C.E.

AU - Hollmann, Frank

PY - 2019

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AB - Elemental metals are shown to be suitable sacrificial electron donors to drive the stereoselective reduction of conjugated C=C double bonds using Old Yellow Enzymes as catalysts. Both direct electron transfer from the metal to the enzyme as well as mediated electron transfer is feasible, although the latter excels by higher reaction rates. The general applicability of this new chemoenzymatic reduction method is demonstrated, and current limitations are outlined.

KW - conjugated double bonds

KW - direct regeneration

KW - metals

KW - old yellow enzymes

KW - stereoselective reduction

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Metals in Biotechnology: Cr-Driven Stereoselective Reduction of Conjugated C=C Double Bonds

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