Methyltransferases: Functions and Applications

Eman Abdelraheem, Benjamin Thair, Romina Fernández Varela, Emely Jockmann, Désirée Popadić, Helen C. Hailes, John M. Ward, Peter Leon Hagedoorn, Ulf Hanefeld*, More Authors

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)
51 Downloads (Pure)

Abstract

In this review the current state-of-the-art of S-adenosylmethionine (SAM)-dependent methyltransferases and SAM are evaluated. Their structural classification and diversity is introduced and key mechanistic aspects presented which are then detailed further. Then, catalytic SAM as a target for drugs, and approaches to utilise SAM as a cofactor in synthesis are introduced with different supply and regeneration approaches evaluated. The use of SAM analogues are also described. Finally O-, N-, C- and S-MTs, their synthetic applications and potential for compound diversification is given.

Original languageEnglish
Article numbere202200212
Number of pages20
JournalChemBioChem
Volume23
Issue number18
DOIs
Publication statusPublished - 2022

Keywords

  • biocatalysis
  • enzymes
  • methyltransferases
  • S-adenosyl-l-methionine

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