TY - JOUR
T1 - Methyltransferases
T2 - Functions and Applications
AU - Abdelraheem, Eman
AU - Thair, Benjamin
AU - Varela, Romina Fernández
AU - Jockmann, Emely
AU - Popadić, Désirée
AU - Hailes, Helen C.
AU - Ward, John M.
AU - Hagedoorn, Peter Leon
AU - Hanefeld, Ulf
AU - More Authors, null
PY - 2022
Y1 - 2022
N2 - In this review the current state-of-the-art of S-adenosylmethionine (SAM)-dependent methyltransferases and SAM are evaluated. Their structural classification and diversity is introduced and key mechanistic aspects presented which are then detailed further. Then, catalytic SAM as a target for drugs, and approaches to utilise SAM as a cofactor in synthesis are introduced with different supply and regeneration approaches evaluated. The use of SAM analogues are also described. Finally O-, N-, C- and S-MTs, their synthetic applications and potential for compound diversification is given.
AB - In this review the current state-of-the-art of S-adenosylmethionine (SAM)-dependent methyltransferases and SAM are evaluated. Their structural classification and diversity is introduced and key mechanistic aspects presented which are then detailed further. Then, catalytic SAM as a target for drugs, and approaches to utilise SAM as a cofactor in synthesis are introduced with different supply and regeneration approaches evaluated. The use of SAM analogues are also described. Finally O-, N-, C- and S-MTs, their synthetic applications and potential for compound diversification is given.
KW - biocatalysis
KW - enzymes
KW - methyltransferases
KW - S-adenosyl-l-methionine
UR - http://www.scopus.com/inward/record.url?scp=85133502568&partnerID=8YFLogxK
U2 - 10.1002/cbic.202200212
DO - 10.1002/cbic.202200212
M3 - Review article
C2 - 35691829
AN - SCOPUS:85133502568
SN - 1439-4227
VL - 23
JO - ChemBioChem
JF - ChemBioChem
IS - 18
M1 - e202200212
ER -