Michaelis-Menten kinetics under non-isothermal conditions

Anders Lervik*, S.H. Bedeaux Kjelstrup, Hong Qian

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)


We extend the celebrated Michaelis-Menten kinetics description of an enzymatic reaction taking into consideration the presence of a thermal driving force. A coupling of chemical and thermal driving forces is expected from the principle of non-equilibrium thermodynamics, and specifically we obtain an additional term to the classical Michaelis-Menten kinetic equation, which describes the coupling in terms of a single parameter. A companion equation for the heat flux is also derived, which actually can exist even in the absence of a temperature difference. Being thermodynamic in nature, this result is general and independent of the detailed mechanism of the coupling. Conditions for the experimental verification of the new equation are discussed.

Original languageEnglish
Pages (from-to)1317-1324
JournalPhysical Chemistry Chemical Physics
Issue number2
Publication statusPublished - 2015


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