Michaelis-Menten kinetics under non-isothermal conditions

Anders Lervik, S.H. Bedeaux Kjelstrup, Hong Qian

Research output: Contribution to journalArticleScientificpeer-review

9 Citations (Scopus)

Abstract

We extend the celebrated Michaelis-Menten kinetics description of an enzymatic reaction taking into consideration the presence of a thermal driving force. A coupling of chemical and thermal driving forces is expected from the principle of non-equilibrium thermodynamics, and specifically we obtain an additional term to the classical Michaelis-Menten kinetic equation, which describes the coupling in terms of a single parameter. A companion equation for the heat flux is also derived, which actually can exist even in the absence of a temperature difference. Being thermodynamic in nature, this result is general and independent of the detailed mechanism of the coupling. Conditions for the experimental verification of the new equation are discussed.

Original languageEnglish
Pages (from-to)1317-1324
JournalPhysical Chemistry Chemical Physics
Volume17
Issue number2
DOIs
Publication statusPublished - 2015

Fingerprint

Dive into the research topics of 'Michaelis-Menten kinetics under non-isothermal conditions'. Together they form a unique fingerprint.

Cite this