Microelectromechanical Organs-on-Chip

Research output: Chapter in Book/Conference proceedings/Edited volumeConference contributionScientificpeer-review

Abstract

Stemming from the convergence of tissue engineering and microfluidics, organ-on-chip (OoC) technology can reproduce in vivo-like dynamic microphysiological environments for tissues in vitro. The possibility afforded by OoC devices of realistic recapitulation of tissue and organ (patho)physiology may hold the key to bridge the current translational gap in drug development, and possibly foster personalized medicine. Here we underline the biotechnological convergence at the root of OoC technology, and outline research tracks under development in our group at TU Delft along two main directions: fabrication of innovative microelectromechanical OoC devices, integrating stimulation and sensing of tissue activity, and their embedding within advanced platforms for pre-clinical research. We conclude with remarks on the role of open technology platforms for the broader establishment of OoC technology in pre-clinical research and drug development.
Original languageEnglish
Title of host publication21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021
PublisherIEEE
Pages102-107
Number of pages6
ISBN (Electronic)978-1-6654-1267-4
ISBN (Print)978-1-6654-4845-1
DOIs
Publication statusPublished - 2021
Event2021 21st International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers) - Virtual at Orlando, United States
Duration: 20 Jun 202124 Jun 2021
Conference number: 21st

Publication series

Name21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021

Conference

Conference2021 21st International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers)
CountryUnited States
CityVirtual at Orlando
Period20/06/2124/06/21

Bibliographical note

Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care

Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

Keywords

  • Actuators
  • microelectrode arrays
  • microfabrication
  • open technology platforms
  • organ-on-chip
  • sensors
  • tissues

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