Mimicking the nuclear pore complex using nanopores

Adithya Ananth

Research output: ThesisDissertation (TU Delft)

33 Downloads (Pure)

Abstract

Nuclear pore complexes acts as a gatekeeper for molecular transport between the nucleus and the cytoplasm in eukaryotic cells. The central NPC channel is filled with intrinsically disordered FG domains (phenylalanine (F), glycine (G)) that are responsible for the fascinating selectivity of NPCs, for which the underlying mechanism is still under considerable debate. In this thesis, a minimalistic mimic of (NPCs) was constructed using solid-state nanopore and DNA origami to study the spatial arrangement and transport process.
Original languageEnglish
Awarding Institution
  • Delft University of Technology
Supervisors/Advisors
  • Dekker, C., Supervisor
Award date10 Apr 2018
Print ISBNs9789085933427
DOIs
Publication statusPublished - 2018

Keywords

  • Single-molecule
  • solid-state nanopore
  • nuclear pore complex
  • proteins
  • ionic conductance
  • DNA origami
  • surface chemistry

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