Miniaturization of Process Analytical Technology: from Concept to Reality

Research output: ThesisDissertation (TU Delft)

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Continuous biomanufacturing is considered the future phase for the optimization of production processes in the biopharmaceutical industry. Productivity, product quality and consistency are greatly improved while production costs and environmental footprint are drastically reduced. The manufacturing of monoclonal antibodies (mAbs), an important biopharmaceutical in the treatment of cancers, autoimmune disorders, and, more recently, COVID-19, is eligible for this continuous processing due to patent expiration and the subsequent need to lower manufacturing costs...
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Delft University of Technology
  • Ottens, M., Supervisor
  • Eppink, M., Supervisor, External person
Award date27 Oct 2023
Print ISBNs978-94-6384-473-4
Publication statusPublished - 2023


  • Antibody aggregation
  • Continuous Biomanufacturing
  • Process Analytical Technology (PAT)
  • Microfluidic Sensor
  • Fluorescent Dyes


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