Miniaturization of Process Analytical Technology: from Concept to Reality

M. Neves Sao Pedro

doi:10.4233/uuid:ec3f81c3-1bb4-4724-9f97-fff46e3c1c66

Miniaturization of Process Analytical Technology: from Concept to Reality

M. Neves Sao Pedro

BT/Bioprocess Engineering

Research output: Thesis › Dissertation (TU Delft)

145 Downloads (Pure)

Abstract

Continuous biomanufacturing is considered the future phase for the optimization of production processes in the biopharmaceutical industry. Productivity, product quality and consistency are greatly improved while production costs and environmental footprint are drastically reduced. The manufacturing of monoclonal antibodies (mAbs), an important biopharmaceutical in the treatment of cancers, autoimmune disorders, and, more recently, COVID-19, is eligible for this continuous processing due to patent expiration and the subsequent need to lower manufacturing costs...

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Delft University of Technology
Supervisors/Advisors	Ottens, M., Promotor Eppink, M., Promotor, External person
Award date	27 Oct 2023
Print ISBNs	978-94-6384-473-4
DOIs	https://doi.org/10.4233/uuid:ec3f81c3-1bb4-4724-9f97-fff46e3c1c66
Publication status	Published - 2023

Keywords

Antibody aggregation
Continuous Biomanufacturing
Process Analytical Technology (PAT)
Microfluidic Sensor
Fluorescent Dyes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.4233/uuid:ec3f81c3-1bb4-4724-9f97-fff46e3c1c66

PhD Thesis_Miniaturization of PATFinal published version, 22.1 MBLicence: CC BY-NC-SA

4 Article
1 Review article

Application of a fluorescent dye-based microfluidic sensor for real-time detection of mAb aggregates
São Pedro, M. N., Eppink, M. H. M. & Ottens, M., 2023, In: Biotechnology Progress. 40 (2024), 5, 12 p., e3355.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
4 Citations (Scopus)

68 Downloads (Pure)
Real-time detection of mAb aggregates in an integrated downstream process
São Pedro, M. N., Isaksson, M., Gomis-Fons, J., Eppink, M. H. M., Nilsson, B. & Ottens, M., 2023, In: Biotechnology and Bioengineering. 120, 10, p. 2989-3000 12 p.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
5 Citations (Scopus)

75 Downloads (Pure)
Design of a microfluidic mixer channel: First steps into creating a fluorescent dye-based biosensor for mAb aggregate detection
São Pedro, M. N., Santos, M. S., Eppink, M. H. M. & Ottens, M., 2022, In: Biotechnology Journal. 18, 1, 10 p., 2200332.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
3 Citations (Scopus)

87 Downloads (Pure)

Cite this

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title = "Miniaturization of Process Analytical Technology: from Concept to Reality",

abstract = "Continuous biomanufacturing is considered the future phase for the optimization of production processes in the biopharmaceutical industry. Productivity, product quality and consistency are greatly improved while production costs and environmental footprint are drastically reduced. The manufacturing of monoclonal antibodies (mAbs), an important biopharmaceutical in the treatment of cancers, autoimmune disorders, and, more recently, COVID-19, is eligible for this continuous processing due to patent expiration and the subsequent need to lower manufacturing costs...",

keywords = "Antibody aggregation, Continuous Biomanufacturing, Process Analytical Technology (PAT), Microfluidic Sensor, Fluorescent Dyes",

author = "{Neves Sao Pedro}, M.",

year = "2023",

doi = "10.4233/uuid:ec3f81c3-1bb4-4724-9f97-fff46e3c1c66",

language = "English",

isbn = "978-94-6384-473-4",

type = "Dissertation (TU Delft)",

school = "Delft University of Technology",

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AU - Neves Sao Pedro, M.

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AB - Continuous biomanufacturing is considered the future phase for the optimization of production processes in the biopharmaceutical industry. Productivity, product quality and consistency are greatly improved while production costs and environmental footprint are drastically reduced. The manufacturing of monoclonal antibodies (mAbs), an important biopharmaceutical in the treatment of cancers, autoimmune disorders, and, more recently, COVID-19, is eligible for this continuous processing due to patent expiration and the subsequent need to lower manufacturing costs...

KW - Antibody aggregation

KW - Continuous Biomanufacturing

KW - Process Analytical Technology (PAT)

KW - Microfluidic Sensor

KW - Fluorescent Dyes

U2 - 10.4233/uuid:ec3f81c3-1bb4-4724-9f97-fff46e3c1c66

DO - 10.4233/uuid:ec3f81c3-1bb4-4724-9f97-fff46e3c1c66

M3 - Dissertation (TU Delft)

SN - 978-94-6384-473-4

ER -

Miniaturization of Process Analytical Technology: from Concept to Reality

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Research output

Application of a fluorescent dye-based microfluidic sensor for real-time detection of mAb aggregates

Real-time detection of mAb aggregates in an integrated downstream process

Design of a microfluidic mixer channel: First steps into creating a fluorescent dye-based biosensor for mAb aggregate detection

Cite this