Model analysis of the interaction between perfusion pressure, MVO2 and coronary flow control

J. Dankelman, Jos A.E. Spaan

Research output: Chapter in Book/Conference proceedings/Edited volumeConference contributionScientificpeer-review

Abstract

Changes in coronary perfusion pressure affect coronary arterial resistance (autoregulation) as well as myocardial oxygen consumption (Gregg's phenomenon). The interaction between the effects of perfusion pressure and myocardial oxygen consumption on coronary flow control was investigated using a model. This model analysis predicts that autoregulation and Gregg's phenomenon compete with each other in controlling coronary flow. The negative feedback system of the metabolic control system can become a positive feedback system when the level of arterial tone decreases and Gregg's phenomenon becomes more important.

Original languageEnglish
Title of host publicationProceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.
Place of PublicationPiscataway, NJ, USA
PublisherIEEE
Pages1748-1749
Volume4
Publication statusPublished - 1996
EventProceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5) - Amsterdam, Neth
Duration: 31 Oct 19963 Nov 1996

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
ISSN (Print)0589-1019

Conference

ConferenceProceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5)
CityAmsterdam, Neth
Period31/10/963/11/96

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