Modelling the immune system response to epithelial wound infections

Research output: Contribution to journalArticleScientificpeer-review

7 Citations (Scopus)


In this paper, a cell-colony based formalism for the healing of superficial wounds is presented. The paper incorporates the migration, proliferation, and death of constituent cells, in the context of wound healing. The present study considers wound healing under ischemic conditions where a bacterial infection develops, which impairs the motility of the constituent cells. In this work, the performance of the immune response system is incorporated in the sense that migrating leukocyte are modelled which engulf the infectious pathogens. The model is based on both deterministic and stochastic principles. Simulation results are discussed in a biological context.
Original languageEnglish
Pages (from-to)158-169
Number of pages12
JournalJournal of Theoretical Biology
Publication statusPublished - 2016


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