TY - JOUR
T1 - Modelling the immune system response to epithelial wound infections
AU - Vermolen, Fred
AU - Arkesteijn, Liselot
AU - Gefen, A
PY - 2016
Y1 - 2016
N2 - In this paper, a cell-colony based formalism for the healing of superficial wounds is presented. The paper incorporates the migration, proliferation, and death of constituent cells, in the context of wound healing. The present study considers wound healing under ischemic conditions where a bacterial infection develops, which impairs the motility of the constituent cells. In this work, the performance of the immune response system is incorporated in the sense that migrating leukocyte are modelled which engulf the infectious pathogens. The model is based on both deterministic and stochastic principles. Simulation results are discussed in a biological context.
AB - In this paper, a cell-colony based formalism for the healing of superficial wounds is presented. The paper incorporates the migration, proliferation, and death of constituent cells, in the context of wound healing. The present study considers wound healing under ischemic conditions where a bacterial infection develops, which impairs the motility of the constituent cells. In this work, the performance of the immune response system is incorporated in the sense that migrating leukocyte are modelled which engulf the infectious pathogens. The model is based on both deterministic and stochastic principles. Simulation results are discussed in a biological context.
U2 - 10.1016/j.jtbi.2015.12.030
DO - 10.1016/j.jtbi.2015.12.030
M3 - Article
SN - 0022-5193
VL - 393
SP - 158
EP - 169
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
ER -