Modelling the Iono-Acoustic Wave Field for Proton Beam Range Verification

Koen van Dongen, Anne de Blécourt, Eelco Lens, Dennis Schaart, Frans Vos

Research output: Chapter in Book/Conference proceedings/Edited volumeConference contributionScientificpeer-review

1 Citation (Scopus)
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In proton therapy, cancer patients are irradiated with high energy protons. For a successful treatment it is important that the location with the highest energy deposition, the so-called Bragg-peak, is located inside the tumor and not in the healthy surrounding tissue. Here, we investigate if the iono-acoustic wave field generated by the protons can be used to monitor the Bragg-peak location during treatment. To this end we present a new numerical method to model the pressure field generated by a clinical proton pencil beam. To compute the field, we convolve a 3-D Greens function, representing the impulse response of the medium, with a volume density of injection rate source. This source describes the expansion of the medium due to a local temperature increase caused by the energy deposited by the protons. To image the proton dose distribution, we first measure the pressure field synthetically by a matrix transducer positioned below the Bragg peak in a plane parallel to the beam. Next, we use these measurements to solve the linear inverse problem iteratively. To regularize the inversion, we take the temporal behavior of the dose deposition as prior knowledge. For the presented example, where the pencil beam has a proton range of 63 mm we are able to reconstruct the location of the Bragg peak within 4 mm accuracy.
Original languageEnglish
Title of host publication2018 IEEE International Ultrasonics Symposium (IUS)
Number of pages4
ISBN (Electronic)978-1-5386-3425-7
Publication statusPublished - 2018
Event2018 IEEE International Ultrasonics Symposium, IUS 2018 - Portopia Hotel, Kobe, Japan
Duration: 22 Oct 201825 Oct 2018


Conference2018 IEEE International Ultrasonics Symposium, IUS 2018
Abbreviated titleIUS 2018

Bibliographical note

Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.


  • iono-acoustics
  • bragg peak localization
  • imgaging


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