TY - JOUR
T1 - Molecular chaperones, evolution and medicine
AU - Csermely, Peter
AU - Soti, Csaba
AU - Kalmar, Eva
AU - Papp, Eszter
AU - Pato, Balint
AU - Vermes, Akos
AU - Sreedhar, Amere S.
PY - 2003
Y1 - 2003
N2 - Protein folding has numerous steps, which need assistance in vivo. Molecular chaperones are required for many proteins to fold, or re-fold into native structures forming an ancient, primary system for 'intracellular self-defense'. Molecular chaperones participate in the organization of the cytoarchitecture, were necessary for the development of modern enzymes and - by stabilizing the genome - for the development of the first stable cells. They have a profound importance in medical practice. Chaperone induction provides cytoprotection in various pathological conditions, while chaperone inhibition can be an efficient tool to fight against cancer. Chaperones are inefficient enzymes and have low-affinity interactions, therefore their assays require unusual methods, which will be summarized in the concluding part of the paper.
AB - Protein folding has numerous steps, which need assistance in vivo. Molecular chaperones are required for many proteins to fold, or re-fold into native structures forming an ancient, primary system for 'intracellular self-defense'. Molecular chaperones participate in the organization of the cytoarchitecture, were necessary for the development of modern enzymes and - by stabilizing the genome - for the development of the first stable cells. They have a profound importance in medical practice. Chaperone induction provides cytoprotection in various pathological conditions, while chaperone inhibition can be an efficient tool to fight against cancer. Chaperones are inefficient enzymes and have low-affinity interactions, therefore their assays require unusual methods, which will be summarized in the concluding part of the paper.
KW - Heat shock proteins
KW - Low affinity
KW - Molecular chaperones
KW - Protein folding
KW - Stress proteins
UR - http://www.scopus.com/inward/record.url?scp=1642574351&partnerID=8YFLogxK
U2 - 10.1016/j.theochem.2003.08.048
DO - 10.1016/j.theochem.2003.08.048
M3 - Article
AN - SCOPUS:1642574351
SN - 0166-1280
VL - 666-667
SP - 373
EP - 380
JO - Journal of Molecular Structure: THEOCHEM
JF - Journal of Molecular Structure: THEOCHEM
ER -