MRI Contrast Agents in Glycobiology

Carlos F.G.C. Geraldes*, Joop A. Peters

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)
52 Downloads (Pure)

Abstract

Molecular recognition involving glycoprotein-mediated interactions is ubiquitous in both normal and pathological natural processes. Therefore, visualization of these interactions and the extent of expression of the sugars is a challenge in medical diagnosis, monitoring of therapy, and drug design. Here, we review the literature on the development and validation of probes for magnetic resonance imaging using carbohydrates either as targeting vectors or as a target. Lectins are important targeting vectors for carbohydrate end groups, whereas selectins, the asialoglycoprotein receptor, sialic acid end groups, hyaluronic acid, and glycated serum and hemoglobin are interesting carbohydrate targets.

Original languageEnglish
Article number8297
Number of pages38
JournalMolecules
Volume27
Issue number23
DOIs
Publication statusPublished - 2022

Keywords

  • asialoglycoprotein receptor
  • biomarkers
  • diagnostic agents
  • glycohemoglobin
  • lectins
  • magnetic resonance contrast agents
  • selectins
  • sialic acid
  • theranostics

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