TY - JOUR
T1 - Multicomponent Mechanical Characterization of Atherosclerotic Human Coronary Arteries
T2 - An Experimental and Computational Hybrid Approach
AU - Guvenir Torun, Su
AU - Torun, Hakki M.
AU - Hansen, Hendrik H.G.
AU - Gandini, Giulia
AU - Berselli, Irene
AU - Codazzi, Veronica
AU - de Korte, Chris L.
AU - van der Steen, Antonius F.W.
AU - Migliavacca, Francesco
AU - Chiastra, Claudio
AU - Akyildiz, Ali C.
PY - 2021
Y1 - 2021
N2 - Atherosclerotic plaque rupture in coronary arteries, an important trigger of myocardial infarction, is shown to correlate with high levels of pressure-induced mechanical stresses in plaques. Finite element (FE) analyses are commonly used for plaque stress assessment. However, the required information of heterogenous material properties of atherosclerotic coronaries remains to be scarce. In this work, we characterized the component-wise mechanical properties of atherosclerotic human coronary arteries. To achieve this, we performed ex vivo inflation tests on post-mortem human coronary arteries and developed an inverse FE modeling (iFEM) pipeline, which combined high-frequency ultrasound deformation measurements, a high-field magnetic resonance-based artery composition characterization, and a machine learning-based Bayesian optimization (BO) with uniqueness assessment. By using the developed pipeline, 10 cross-sections from five atherosclerotic human coronary arteries were analyzed, and the Yeoh material model constants of the fibrous intima and arterial wall components were determined. This work outlines the developed pipeline and provides the knowledge of non-linear, multicomponent mechanical properties of atherosclerotic human coronary arteries.
AB - Atherosclerotic plaque rupture in coronary arteries, an important trigger of myocardial infarction, is shown to correlate with high levels of pressure-induced mechanical stresses in plaques. Finite element (FE) analyses are commonly used for plaque stress assessment. However, the required information of heterogenous material properties of atherosclerotic coronaries remains to be scarce. In this work, we characterized the component-wise mechanical properties of atherosclerotic human coronary arteries. To achieve this, we performed ex vivo inflation tests on post-mortem human coronary arteries and developed an inverse FE modeling (iFEM) pipeline, which combined high-frequency ultrasound deformation measurements, a high-field magnetic resonance-based artery composition characterization, and a machine learning-based Bayesian optimization (BO) with uniqueness assessment. By using the developed pipeline, 10 cross-sections from five atherosclerotic human coronary arteries were analyzed, and the Yeoh material model constants of the fibrous intima and arterial wall components were determined. This work outlines the developed pipeline and provides the knowledge of non-linear, multicomponent mechanical properties of atherosclerotic human coronary arteries.
KW - atherosclerosis
KW - Bayesian optimization
KW - coronary artery
KW - finite element analysis
KW - inflation test
KW - material constant
KW - ultrasound
KW - Yeoh model
UR - http://www.scopus.com/inward/record.url?scp=85115375991&partnerID=8YFLogxK
U2 - 10.3389/fphys.2021.733009
DO - 10.3389/fphys.2021.733009
M3 - Article
AN - SCOPUS:85115375991
SN - 1664-042X
VL - 12
JO - Frontiers in Physiology
JF - Frontiers in Physiology
M1 - 733009
ER -