Multicomponent MR fingerprinting reconstruction using joint-sparsity and low-rank constraints

Martijn Nagtegaal*, Emiel Hartsema, Kirsten Koolstra, Frans Vos

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Purpose: To develop an efficient algorithm for multicomponent MR fingerprinting (MC-MRF) reconstructions directly from highly undersampled data without making prior assumptions about tissue relaxation times and expected number of tissues. Methods: The proposed method reconstructs MC-MRF maps from highly undersampled data by iteratively applying a joint-sparsity constraint to the estimated tissue components. Intermediate component maps are obtained by a low-rank multicomponent alternating direction method of multipliers (MC-ADMM) including the non-negativity of tissue weights as an extra regularization term. Over iterations, the used dictionary compression is adjusted. The proposed method (k-SPIJN) is compared with a two-step approach in which image reconstruction and multicomponent estimations are performed sequentially and tested in numerical simulations and in vivo by applying different undersampling factors in eight healthy volunteers. In the latter case, fully sampled data serves as the reference. Results: The proposed method shows improved precision and accuracy in simulations compared with a state-of-art sequential approach. Obtained in vivo magnetization fraction maps for different tissue types show reduced systematic errors and reduced noise-like effects. Root mean square errors in estimated magnetization fraction maps significantly reduce from 13.0% (Formula presented.) 5.8% with the conventional, two-step approach to 9.6% (Formula presented.) 3.9% and 9.6% (Formula presented.) 3.2% with the proposed MC-ADMM and k-SPIJN methods, respectively. Mean standard deviation in homogeneous white matter regions reduced significantly from 8.6% to 2.9% (two step vs. k-SPIJN). Conclusion: The proposed MC-ADMM and k-SPIJN reconstruction methods estimate MC-MRF maps from highly undersampled data resulting in improved image quality compared with the existing method.

Original languageEnglish
Pages (from-to)286-298
Number of pages13
JournalMagnetic Resonance in Medicine
Issue number1
Publication statusPublished - 2022


  • MR fingerprinting
  • MR reconstruction
  • multicomponent analysis
  • myelin water imaging
  • quantitative MRI

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