Multimodal imaging combining time-domain near-infrared optical tomography and continuous-wave fluorescence molecular tomography

Wuwei Ren, Jingjing Jiang, Aldo Di Costanzo Mata, Alexander Kalyanov, Jorge Ripoll, Scott Lindner, Edoardo Charbon, Chao Zhang, Markus Rudin, Martin Wolf

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Abstract

Fluorescence molecular tomography (FMT) emerges as a powerful non-invasive imaging tool with the ability to resolve fluorescence signals from sources located deep in living tissues. Yet, the accuracy of FMT reconstruction depends on the deviation of the assumed optical properties from the actual values. In this work, we improved the accuracy of the initial optical properties required for FMT using a new-generation time-domain (TD) near-infrared optical tomography (NIROT) system, which effectively decouples scattering and absorption coefficients. We proposed a multimodal paradigm combining TD-NIROT and continuous-wave (CW) FMT. Both numerical simulation and experiments were performed on a heterogeneous phantom containing a fluorescent inclusion. The results demonstrate significant improvement in the FMT reconstruction by taking the NIROT-derived optical properties as prior information. The multimodal method is attractive for preclinical studies and tumor diagnostics since both functional and molecular information can be obtained.

Original languageEnglish
Pages (from-to)9860-9874
Number of pages15
JournalOptics Express
Volume28
Issue number7
DOIs
Publication statusPublished - 30 Mar 2020

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    Ren, W., Jiang, J., Di Costanzo Mata, A., Kalyanov, A., Ripoll, J., Lindner, S., Charbon, E., Zhang, C., Rudin, M., & Wolf, M. (2020). Multimodal imaging combining time-domain near-infrared optical tomography and continuous-wave fluorescence molecular tomography. Optics Express, 28(7), 9860-9874. https://doi.org/10.1364/OE.385392