Multimodal imaging combining time-domain near-infrared optical tomography and continuous-wave fluorescence molecular tomography

Wuwei Ren, Jingjing Jiang, Aldo Di Costanzo Mata, Alexander Kalyanov, Jorge Ripoll, Scott Lindner, Edoardo Charbon, Chao Zhang, Markus Rudin, Martin Wolf

    Research output: Contribution to journalArticleScientificpeer-review

    12 Citations (Scopus)
    112 Downloads (Pure)

    Abstract

    Fluorescence molecular tomography (FMT) emerges as a powerful non-invasive imaging tool with the ability to resolve fluorescence signals from sources located deep in living tissues. Yet, the accuracy of FMT reconstruction depends on the deviation of the assumed optical properties from the actual values. In this work, we improved the accuracy of the initial optical properties required for FMT using a new-generation time-domain (TD) near-infrared optical tomography (NIROT) system, which effectively decouples scattering and absorption coefficients. We proposed a multimodal paradigm combining TD-NIROT and continuous-wave (CW) FMT. Both numerical simulation and experiments were performed on a heterogeneous phantom containing a fluorescent inclusion. The results demonstrate significant improvement in the FMT reconstruction by taking the NIROT-derived optical properties as prior information. The multimodal method is attractive for preclinical studies and tumor diagnostics since both functional and molecular information can be obtained.

    Original languageEnglish
    Pages (from-to)9860-9874
    Number of pages15
    JournalOptics Express
    Volume28
    Issue number7
    DOIs
    Publication statusPublished - 30 Mar 2020

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