Multimodal Sentiment Analysis in Real-life Media (MuSe) 2020 is a Challenge-based Workshop focusing on the tasks of sentiment recognition, as well as emotion-target engagement and trustworthiness detection by means of more comprehensively integrating the audio-visual and language modalities. The purpose of MuSe 2020 is to bring together communities from different disciplines; mainly, the audio-visual emotion recognition community (signal-based), and the sentiment analysis community (symbol-based). We present three distinct sub-challenges: MuSe-Wild, which focuses on continuous emotion (arousal and valence) prediction; MuSe-Topic, in which participants recognise 10 domain-specific topics as the target of 3-class (low, medium, high) emotions; and MuSe-Trust, in which the novel aspect of trustworthiness is to be predicted. In this paper, we provide detailed information on MuSe-CAR, the first of its kind in-the-wild database, which is utilised for the challenge, as well as the state-of-the-art features and modelling approaches applied. For each sub-challenge, a competitive baseline for participants is set; namely, on test we report for MuSe-Wild a combined (valence and arousal) CCC of .2568, for MuSe-Topic a score (computed as 0.34∗UAR + 0.66∗F1) of 76.78 % on the 10-class topic and 40.64 % on the 3-class emotion prediction, and for MuSe-Trust a CCC of .4359.