TY - JOUR
T1 - Nanocarrier-Mediated Photochemotherapy and Photoradiotherapy
AU - Denkova, Antonia G.
AU - de Kruijff, Robine M.
AU - Serra-Crespo, Pablo
N1 - Accepted Author Manuscript
PY - 2017
Y1 - 2017
N2 - Photothermal therapy (PTT) and photodynamic therapy (PDT) both utilize light to induce a therapeutic effect. These therapies are rapidly gaining importance due to the noninvasiveness of light and the limited adverse effect associated with these treatments. However, most preclinical studies show that complete elimination of tumors is rarely observed. Combining PDT and PTT with chemotherapy or radiotherapy can improve the therapeutic outcome and simultaneously decrease side effects of these conventional treatments. Nanocarriers can help to facilitate such a combined treatment. Here, the most recent advancements in the field of photochemotherapy and photoradiotherapy, in which nanocarriers are employed, are reviewed.
AB - Photothermal therapy (PTT) and photodynamic therapy (PDT) both utilize light to induce a therapeutic effect. These therapies are rapidly gaining importance due to the noninvasiveness of light and the limited adverse effect associated with these treatments. However, most preclinical studies show that complete elimination of tumors is rarely observed. Combining PDT and PTT with chemotherapy or radiotherapy can improve the therapeutic outcome and simultaneously decrease side effects of these conventional treatments. Nanocarriers can help to facilitate such a combined treatment. Here, the most recent advancements in the field of photochemotherapy and photoradiotherapy, in which nanocarriers are employed, are reviewed.
KW - Chemotherapy
KW - Combined phototherapies
KW - Nanocarriers
KW - Radiation therapy
UR - http://resolver.tudelft.nl/uuid:f1e7040e-a9b4-4b9b-943b-ddb046a1c124
UR - http://www.scopus.com/inward/record.url?scp=85039171361&partnerID=8YFLogxK
U2 - 10.1002/adhm.201701211
DO - 10.1002/adhm.201701211
M3 - Article
AN - SCOPUS:85039171361
SN - 2192-2640
SP - 61
JO - Advanced Healthcare Materials
JF - Advanced Healthcare Materials
M1 - 1701211
ER -