Nanomaterials for bone tissue regeneration: Updates and future perspectives

Michael J Hill; Baowen Qi; Rasoul Bayaniahangar; Vida Araban; Zahra Bakhtiary; Michael R. Doschak; Brian C. Goh; Mohammadreza Shokouhimehr; Hojatollah Vali; John F. Presley; Amir A. Zadpoor; Mitchel B. Harris; Parisa P.S.S. Abadi; Morteza Mahmoudi

doi:10.2217/nnm-2018-0445

Nanomaterials for bone tissue regeneration: Updates and future perspectives

Michael J Hill, Baowen Qi, Rasoul Bayaniahangar, Vida Araban, Zahra Bakhtiary, Michael R. Doschak, Brian C. Goh, Mohammadreza Shokouhimehr, Hojatollah Vali, John F. Presley, Amir A. Zadpoor, Mitchel B. Harris^*, Parisa P.S.S. Abadi, Morteza Mahmoudi

^*Corresponding author for this work

Biomaterials & Tissue Biomechanics

Research output: Contribution to journal › Review article › peer-review

37 Citations (Scopus)

Abstract

Joint replacement and bone reconstructive surgeries are on the rise globally. Current strategies for implants and bone regeneration are associated with poor integration and healing resulting in repeated surgeries. A multidisciplinary approach involving basic biological sciences, tissue engineering, regenerative medicine and clinical research is required to overcome this problem. Considering the nanostructured nature of bone, expertise and resources available through recent advancements in nanobiotechnology enable researchers to design and fabricate devices and drug delivery systems at the nanoscale to be more compatible with the bone tissue environment. The focus of this review is to present the recent progress made in the rationale and design of nanomaterials for tissue engineering and drug delivery relevant to bone regeneration.

Original language	English
Pages (from-to)	2987-3006
Journal	Nanomedicine
Volume	14
Issue number	22
DOIs	https://doi.org/10.2217/nnm-2018-0445
Publication status	Published - 2019

Keywords

bone
drug delivery
nanomaterials
nanotechnology
tissue engineering

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title = "Nanomaterials for bone tissue regeneration: Updates and future perspectives",

abstract = "Joint replacement and bone reconstructive surgeries are on the rise globally. Current strategies for implants and bone regeneration are associated with poor integration and healing resulting in repeated surgeries. A multidisciplinary approach involving basic biological sciences, tissue engineering, regenerative medicine and clinical research is required to overcome this problem. Considering the nanostructured nature of bone, expertise and resources available through recent advancements in nanobiotechnology enable researchers to design and fabricate devices and drug delivery systems at the nanoscale to be more compatible with the bone tissue environment. The focus of this review is to present the recent progress made in the rationale and design of nanomaterials for tissue engineering and drug delivery relevant to bone regeneration.",

keywords = "bone, drug delivery, nanomaterials, nanotechnology, tissue engineering",

author = "{J Hill}, Michael and Baowen Qi and Rasoul Bayaniahangar and Vida Araban and Zahra Bakhtiary and Doschak, {Michael R.} and Goh, {Brian C.} and Mohammadreza Shokouhimehr and Hojatollah Vali and Presley, {John F.} and Zadpoor, {Amir A.} and Harris, {Mitchel B.} and Abadi, {Parisa P.S.S.} and Morteza Mahmoudi",

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AU - J Hill, Michael

AU - Qi, Baowen

AU - Bayaniahangar, Rasoul

AU - Araban, Vida

AU - Bakhtiary, Zahra

AU - Doschak, Michael R.

AU - Goh, Brian C.

AU - Shokouhimehr, Mohammadreza

AU - Vali, Hojatollah

AU - Presley, John F.

AU - Zadpoor, Amir A.

AU - Harris, Mitchel B.

AU - Abadi, Parisa P.S.S.

AU - Mahmoudi, Morteza

PY - 2019

Y1 - 2019

N2 - Joint replacement and bone reconstructive surgeries are on the rise globally. Current strategies for implants and bone regeneration are associated with poor integration and healing resulting in repeated surgeries. A multidisciplinary approach involving basic biological sciences, tissue engineering, regenerative medicine and clinical research is required to overcome this problem. Considering the nanostructured nature of bone, expertise and resources available through recent advancements in nanobiotechnology enable researchers to design and fabricate devices and drug delivery systems at the nanoscale to be more compatible with the bone tissue environment. The focus of this review is to present the recent progress made in the rationale and design of nanomaterials for tissue engineering and drug delivery relevant to bone regeneration.

AB - Joint replacement and bone reconstructive surgeries are on the rise globally. Current strategies for implants and bone regeneration are associated with poor integration and healing resulting in repeated surgeries. A multidisciplinary approach involving basic biological sciences, tissue engineering, regenerative medicine and clinical research is required to overcome this problem. Considering the nanostructured nature of bone, expertise and resources available through recent advancements in nanobiotechnology enable researchers to design and fabricate devices and drug delivery systems at the nanoscale to be more compatible with the bone tissue environment. The focus of this review is to present the recent progress made in the rationale and design of nanomaterials for tissue engineering and drug delivery relevant to bone regeneration.

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KW - drug delivery

KW - nanomaterials

KW - nanotechnology

KW - tissue engineering

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DO - 10.2217/nnm-2018-0445

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VL - 14

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EP - 3006

JO - Nanomedicine

JF - Nanomedicine

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ER -

Nanomaterials for bone tissue regeneration: Updates and future perspectives

Abstract

Keywords

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