Nonlinear propagation of ultrasound in microbubble populations: Explore collective dynamics

Research output: ThesisDissertation (TU Delft)

14 Downloads (Pure)

Abstract

For over 50 years, medical ultrasound has been a pioneering force in healthcare, seamlessly blending diagnostic and therapeutic applications. In diagnostics, ultrasound reveals intricate internal structures based on the generation of acoustic pressure waves in the human body and capturing reflections from tissue and body structures, enabling precise anomaly identification. Simultaneously, in therapy, ultrasound utilizes its acoustic prowess for targeted interventions and submillimeter localization in unconventional cancer treatments like proton therapy. The field has shifted significantly with the advent of nonlinear acoustics, exploring wave propagation phenomena. Contrast agents marked a revolutionary leap, enhancing the specificity, sensitivity, and efficiency of diagnostic and therapeutic ultrasound. Microbubbles, as the most conventionally used agents, exhibit strong nonlinear scattering under ultrasonic excitation, making them suitable for CEUS applications.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Delft University of Technology
Supervisors/Advisors
  • de Jong, N., Supervisor
  • Verweij, M.D., Supervisor
Award date19 Dec 2024
DOIs
Publication statusPublished - 2024

Keywords

  • medical ultrasound
  • nonlinear acoustics
  • contrast-enhanced imaging
  • microbubbles
  • multiple scattering
  • monodisperse
  • polydisperse
  • imaging artifacts
  • proton therapy

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