TY - JOUR
T1 - Normative brain volumetry derived from different reference populations
T2 - impact on single-subject diagnostic assessment in dementia
AU - Vinke, Elisabeth J.
AU - Huizinga, Wyke
AU - Bergtholdt, Martin
AU - Adams, Hieab H.
AU - Steketee, Rebecca M.E.
AU - Papma, Janne M.
AU - De Jong, Frank Jan
AU - Niessen, Wiro J.
AU - Ikram, M. Arfan
AU - More Authors, null
PY - 2019
Y1 - 2019
N2 - Brain imaging data are increasingly made publicly accessible, and volumetric imaging measures derived from population-based cohorts may serve as normative data for individual patient diagnostic assessment. Yet, these normative cohorts are usually not a perfect reflection of a patient's base population, nor are imaging parameters such as field strength or scanner type similar. In this proof of principle study, we assessed differences between reference curves of subcortical structure volumes of normal controls derived from two population-based studies and a case-control study. We assessed the impact of any differences on individual assessment of brain structure volumes. Percentile curves were fitted on the three healthy cohorts. Next, percentile values for these subcortical structures for individual patients from these three cohorts, 91 mild cognitive impairment and 95 Alzheimer's disease cases and patients from the Alzheimer Center, were calculated, based on the distributions of each of the three cohorts. Overall, we found that the subcortical volume normative data from these cohorts are highly interchangeable, suggesting more flexibility in clinical implementation.
AB - Brain imaging data are increasingly made publicly accessible, and volumetric imaging measures derived from population-based cohorts may serve as normative data for individual patient diagnostic assessment. Yet, these normative cohorts are usually not a perfect reflection of a patient's base population, nor are imaging parameters such as field strength or scanner type similar. In this proof of principle study, we assessed differences between reference curves of subcortical structure volumes of normal controls derived from two population-based studies and a case-control study. We assessed the impact of any differences on individual assessment of brain structure volumes. Percentile curves were fitted on the three healthy cohorts. Next, percentile values for these subcortical structures for individual patients from these three cohorts, 91 mild cognitive impairment and 95 Alzheimer's disease cases and patients from the Alzheimer Center, were calculated, based on the distributions of each of the three cohorts. Overall, we found that the subcortical volume normative data from these cohorts are highly interchangeable, suggesting more flexibility in clinical implementation.
KW - Imaging
KW - MRI
KW - Normative data
KW - Subcortical brain volume
UR - http://www.scopus.com/inward/record.url?scp=85071529121&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2019.07.008
DO - 10.1016/j.neurobiolaging.2019.07.008
M3 - Article
AN - SCOPUS:85071529121
SN - 0197-4580
VL - 84
SP - 9
EP - 16
JO - Neurobiology of Aging
JF - Neurobiology of Aging
ER -