Note:Interference technique for minimally invasive, subnanometer, microsecond measurements

I Dujovne, JWJ Kerssemakers, G Cappello, C Dekker

Research output: Contribution to journalArticleScientificpeer-review


We present a novel high-resolution technique for single-molecule experiments, viz., differential traveling wave tracking. This is an interference-based scattering technique where we use gold nanoparticles for high scattering intensities and incorporate differential measurements along one in-plane direction to subtract mechanical noise and drift of the system. In addition, out-of-plane distances are measured via scattered light intensity in a total internal reflectance illumination field. In plane, we demonstrate a rms noise level of only 0.10 nm at 10 kHz and less than 0.5 nm at 600 kHz.
Original languageUndefined/Unknown
JournalReview of Scientific Instruments
Issue number016103
Publication statusPublished - 2010


  • academic journal papers
  • CWTS JFIS < 0.75

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