Novel genetic parts and cultivation strategies for yeast-based conversion of lignocellulosic feedstocks

Maarten Verhoeven

Research output: ThesisDissertation (TU Delft)

61 Downloads (Pure)

Abstract

The recent start-up of several full-scale ‘second generation’ ethanol plants marks a major milestone in the development of Saccharomyces cerevisiae yeast strains for fermentation of lignocellulosic hydrolysates of agricultural residues and energy crops. In contrast to the fermentation of hexose sugar-rich substrates, such as corn syrup or sugar cane bagasse, these hydrolysates contain mixtures of the hexose sugar D-glucose and the pentose sugars D-xylose and L-arabinose. While S. cerevisiae performs excellently in fermenting hexose sugars to ethanol, efficient utilization of pentose sugars required extensive metabolic and evolutionary engineering.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Delft University of Technology
Supervisors/Advisors
  • Pronk, J.T., Supervisor
  • van Maris, A.J.A., Supervisor
Thesis sponsors
Award date6 Sep 2018
Print ISBNs978-94-6186-944-9
DOIs
Publication statusPublished - 2018

Keywords

  • pentose fermentation
  • xylose
  • arabinose
  • Saccharomyces cerevisiae
  • Yeast
  • Biotechnology
  • Lignocellulosic biofuels
  • Ethanol

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