On CRISPR-controlled Proteases

S.P.B. van Beljouw

doi:10.4233/uuid:82a05f19-df6b-463a-b2ab-18e310821262

On CRISPR-controlled Proteases

S.P.B. van Beljouw

BN/Stan Brouns Lab

Research output: Thesis › Dissertation (TU Delft)

54 Downloads (Pure)

Abstract

This dissertation provides an experimental and conceptual characterization of Craspase, a CRISPR-controlled protease. The array of functionalities inherent to Craspase — including precise protein cleavage, guided RNA recognition, and self-regulatory capabilities — highlights the complexity that can emerge from the endless bacterium-virus coevolution.

Original language	English
Awarding Institution	Delft University of Technology
Supervisors/Advisors	Brouns, S.J.J., Promotor Joo, C., Promotor
Award date	7 Jun 2024
Print ISBNs	978-94-6496-132-4
DOIs	https://doi.org/10.4233/uuid:82a05f19-df6b-463a-b2ab-18e310821262
Publication status	Published - 2024

Keywords

CRISPR-Cas
type III-E
prokaryotic immunity
RNA
Craspase
CRISPR-controlled proteases
gRAMP
TPR-CHAT
host-parasite evolution

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10.4233/uuid:82a05f19-df6b-463a-b2ab-18e310821262

On CRISPR-controlled Proteases -- Sam van Beljouw 2024Final published version, 90.2 MB

1 Review article

CRISPR-controlled proteases
van Beljouw, S. P. B. & Brouns, S. J. J., 2024, In: Biochemical Society Transactions. 52, 1, p. 441-453 13 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
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Cite this

@phdthesis{82a05f19df6b463ab2ab18e310821262,

title = "On CRISPR-controlled Proteases",

abstract = "This dissertation provides an experimental and conceptual characterization of Craspase, a CRISPR-controlled protease. The array of functionalities inherent to Craspase — including precise protein cleavage, guided RNA recognition, and self-regulatory capabilities — highlights the complexity that can emerge from the endless bacterium-virus coevolution.",

keywords = "CRISPR-Cas, type III-E, prokaryotic immunity, RNA, Craspase, CRISPR-controlled proteases, gRAMP, TPR-CHAT, host-parasite evolution",

author = "{van Beljouw}, S.P.B.",

year = "2024",

doi = "10.4233/uuid:82a05f19-df6b-463a-b2ab-18e310821262",

language = "English",

isbn = "978-94-6496-132-4",

series = "Casimir PhD Series, Delft-Leiden",

type = "Dissertation (TU Delft)",

school = "Delft University of Technology",

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AU - van Beljouw, S.P.B.

PY - 2024

Y1 - 2024

N2 - This dissertation provides an experimental and conceptual characterization of Craspase, a CRISPR-controlled protease. The array of functionalities inherent to Craspase — including precise protein cleavage, guided RNA recognition, and self-regulatory capabilities — highlights the complexity that can emerge from the endless bacterium-virus coevolution.

AB - This dissertation provides an experimental and conceptual characterization of Craspase, a CRISPR-controlled protease. The array of functionalities inherent to Craspase — including precise protein cleavage, guided RNA recognition, and self-regulatory capabilities — highlights the complexity that can emerge from the endless bacterium-virus coevolution.

KW - CRISPR-Cas

KW - type III-E

KW - prokaryotic immunity

KW - RNA

KW - Craspase

KW - CRISPR-controlled proteases

KW - gRAMP

KW - TPR-CHAT

KW - host-parasite evolution

U2 - 10.4233/uuid:82a05f19-df6b-463a-b2ab-18e310821262

DO - 10.4233/uuid:82a05f19-df6b-463a-b2ab-18e310821262

M3 - Dissertation (TU Delft)

SN - 978-94-6496-132-4

T3 - Casimir PhD Series, Delft-Leiden

ER -

On CRISPR-controlled Proteases

Abstract

Keywords

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Research output

CRISPR-controlled proteases

Cite this