On the Stimulation Artifact Reduction during Electrophysiological Recording of Compound Nerve Action Potentials

Raphael Panskus; Lukas Holzapfel; Wouter A. Serdijn; Vasiliki Giagka

doi:10.1109/EMBC40787.2023.10341179

On the Stimulation Artifact Reduction during Electrophysiological Recording of Compound Nerve Action Potentials

Raphael Panskus^*, Lukas Holzapfel, Wouter A. Serdijn, Vasiliki Giagka

^*Corresponding author for this work

Bio-Electronics

Research output: Chapter in Book/Conference proceedings/Edited volume › Conference contribution › Scientific › peer-review

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Abstract

Recording neuronal activity triggered by electrical impulses is a powerful tool in neuroscience research and neural engineering. It is often applied in acute electrophysiological experimental settings to record compound nerve action potentials. However, the elicited neural response is often distorted by electrical stimulus artifacts, complicating subsequent analysis. In this work, we present a model to better understand the effect of the selected amplifier configuration and the location of the ground electrode in a practical electrophysiological nerve setup. Simulation results show that the stimulus artifact can be reduced by more than an order of magnitude if the placement of the ground electrode, its impedance, and the amplifier configuration are optimized. We experimentally demonstrate the effects in three different settings, in-vivo and in-vitro.

Original language	English
Title of host publication	Proceeding of the 2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
Place of Publication	Piscataway
Publisher	IEEE
Number of pages	5
ISBN (Electronic)	979-8-3503-2447-1
ISBN (Print)	979-8-3503-2448-8
DOIs	https://doi.org/10.1109/EMBC40787.2023.10341179
Publication status	Published - 2023
Event	45th International Conference of the IEEE Engineering in Medicine and Biology - Sydney, Australia Duration: 24 Jul 2023 → 27 Jul 2023 Conference number: 45

Conference

Conference	45th International Conference of the IEEE Engineering in Medicine and Biology
Abbreviated title	EMBC 2023
Country/Territory	Australia
City	Sydney
Period	24/07/23 → 27/07/23

Bibliographical note

Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care
Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

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title = "On the Stimulation Artifact Reduction during Electrophysiological Recording of Compound Nerve Action Potentials",

abstract = "Recording neuronal activity triggered by electrical impulses is a powerful tool in neuroscience research and neural engineering. It is often applied in acute electrophysiological experimental settings to record compound nerve action potentials. However, the elicited neural response is often distorted by electrical stimulus artifacts, complicating subsequent analysis. In this work, we present a model to better understand the effect of the selected amplifier configuration and the location of the ground electrode in a practical electrophysiological nerve setup. Simulation results show that the stimulus artifact can be reduced by more than an order of magnitude if the placement of the ground electrode, its impedance, and the amplifier configuration are optimized. We experimentally demonstrate the effects in three different settings, in-vivo and in-vitro.",

author = "Raphael Panskus and Lukas Holzapfel and Serdijn, {Wouter A.} and Vasiliki Giagka",

note = "Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.; 45th International Conference of the IEEE Engineering in Medicine and Biology, EMBC 2023 ; Conference date: 24-07-2023 Through 27-07-2023",

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doi = "10.1109/EMBC40787.2023.10341179",

language = "English",

isbn = "979-8-3503-2448-8",

booktitle = "Proceeding of the 2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)",

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}

Panskus, R , Holzapfel, L , Serdijn, WA & Giagka, V 2023, On the Stimulation Artifact Reduction during Electrophysiological Recording of Compound Nerve Action Potentials. in Proceeding of the 2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE, Piscataway, 45th International Conference of the IEEE Engineering in Medicine and Biology, Sydney, Australia, 24/07/23. https://doi.org/10.1109/EMBC40787.2023.10341179

On the Stimulation Artifact Reduction during Electrophysiological Recording of Compound Nerve Action Potentials. / Panskus, Raphael ; Holzapfel, Lukas ; Serdijn, Wouter A. et al.
Proceeding of the 2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). Piscataway: IEEE, 2023.

Research output: Chapter in Book/Conference proceedings/Edited volume › Conference contribution › Scientific › peer-review

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T1 - On the Stimulation Artifact Reduction during Electrophysiological Recording of Compound Nerve Action Potentials

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N2 - Recording neuronal activity triggered by electrical impulses is a powerful tool in neuroscience research and neural engineering. It is often applied in acute electrophysiological experimental settings to record compound nerve action potentials. However, the elicited neural response is often distorted by electrical stimulus artifacts, complicating subsequent analysis. In this work, we present a model to better understand the effect of the selected amplifier configuration and the location of the ground electrode in a practical electrophysiological nerve setup. Simulation results show that the stimulus artifact can be reduced by more than an order of magnitude if the placement of the ground electrode, its impedance, and the amplifier configuration are optimized. We experimentally demonstrate the effects in three different settings, in-vivo and in-vitro.

AB - Recording neuronal activity triggered by electrical impulses is a powerful tool in neuroscience research and neural engineering. It is often applied in acute electrophysiological experimental settings to record compound nerve action potentials. However, the elicited neural response is often distorted by electrical stimulus artifacts, complicating subsequent analysis. In this work, we present a model to better understand the effect of the selected amplifier configuration and the location of the ground electrode in a practical electrophysiological nerve setup. Simulation results show that the stimulus artifact can be reduced by more than an order of magnitude if the placement of the ground electrode, its impedance, and the amplifier configuration are optimized. We experimentally demonstrate the effects in three different settings, in-vivo and in-vitro.

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BT - Proceeding of the 2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)

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On the Stimulation Artifact Reduction during Electrophysiological Recording of Compound Nerve Action Potentials

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