Optical coherence tomography attenuation imaging for lipid core detection: an ex-vivo validation study

Muthukaruppan Gnanadesigan, Ali S. Hussain, Stephen White, Simon Scoltock, Andreas Baumbach, Antonius F.W. van der Steen, Evelyn Regar, Thomas W. Johnson, Gijs van Soest

Research output: Contribution to journalArticleScientificpeer-review

11 Citations (Scopus)
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Lipid-core atherosclerotic plaques are associated with disease progression, procedural complications, and cardiac events. Coronary plaque lipid can be quantified in optical coherence tomography (OCT) pullbacks by measurement of lipid arcs and lipid lengths; parameters frequently used in clinical research, but labor intensive and subjective to analyse. In this study, we investigated the ability of quantitative attenuation, derived from intravascular OCT, to detect plaque lipid. Lipid cores are associated with a high attenuation coefficient. We compared the index of plaque attenuation (IPA), a local quantitative measure of attenuation, to the manually measured lipid score (arc and length) on OCT images, and to the plaque characterization ex-vivo. We confirmed a correlation between the IPA and lipid scores (r2 > 0.7). Comparison to histology shows that high attenuation is associated with fibroatheroma, but also with macrophage presence. IPA is a robust, reproducible, and user-independent measure that facilitates quantification of coronary lipid, a potential tool in clinical research and in guiding percutaneous coronary intervention.

Original languageEnglish
Pages (from-to)5-11
Number of pages7
JournalInternational Journal of Cardiovascular Imaging
Issue number1
Publication statusPublished - 1 Jan 2017


  • Attenuation
  • Lipid core plaque
  • Optical coherence tomography

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