Optical coherence tomography attenuation imaging for lipid core detection: an ex-vivo validation study

Muthukaruppan Gnanadesigan, Ali S. Hussain, Stephen White, Simon Scoltock, Andreas Baumbach, Antonius F.W. van der Steen, Evelyn Regar, Thomas W. Johnson, Gijs van Soest

    Research output: Contribution to journalArticleScientificpeer-review

    14 Citations (Scopus)
    19 Downloads (Pure)

    Abstract

    Lipid-core atherosclerotic plaques are associated with disease progression, procedural complications, and cardiac events. Coronary plaque lipid can be quantified in optical coherence tomography (OCT) pullbacks by measurement of lipid arcs and lipid lengths; parameters frequently used in clinical research, but labor intensive and subjective to analyse. In this study, we investigated the ability of quantitative attenuation, derived from intravascular OCT, to detect plaque lipid. Lipid cores are associated with a high attenuation coefficient. We compared the index of plaque attenuation (IPA), a local quantitative measure of attenuation, to the manually measured lipid score (arc and length) on OCT images, and to the plaque characterization ex-vivo. We confirmed a correlation between the IPA and lipid scores (r2 > 0.7). Comparison to histology shows that high attenuation is associated with fibroatheroma, but also with macrophage presence. IPA is a robust, reproducible, and user-independent measure that facilitates quantification of coronary lipid, a potential tool in clinical research and in guiding percutaneous coronary intervention.

    Original languageEnglish
    Pages (from-to)5-11
    Number of pages7
    JournalInternational Journal of Cardiovascular Imaging
    Volume33
    Issue number1
    DOIs
    Publication statusPublished - 1 Jan 2017

    Keywords

    • Attenuation
    • Lipid core plaque
    • Optical coherence tomography

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