Peroxygenases en route to becoming dream catalysts. What are the opportunities and challenges?

Yonghua Wang, Dongming Lan, Rabia Durrani, Frank Hollmann

Research output: Contribution to journalReview articlepeer-review

107 Citations (Scopus)
61 Downloads (Pure)

Abstract

Peroxygenases are promising catalysts for preparative oxyfunctionalization chemistry as they combine the versatility of P450 monooxygenases with simplicity of cofactor-independent enzymes. Though many interesting applications have been reported, today ‘we have only scratched the surface’ and significant efforts are necessary to solve issues related to selectivity of the wild type enzymes and low product titers. For this, further elucidation of the vast natural diversity as well as protein and reaction engineering approaches are discussed.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalCurrent Opinion in Chemical Biology
Volume37
DOIs
Publication statusPublished - 1 Apr 2017

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