Phage Therapy: Going Temperate?

Rodrigo Monteiro, Diana Priscila Pires, Ana Rita Costa, Joana Azeredo

Research output: Contribution to journalReview articleScientificpeer-review

33 Citations (Scopus)

Abstract

Strictly lytic phages have been consensually preferred for phage therapy purposes. In contrast, temperate phages have been avoided due to an inherent capacity to mediate transfer of genes between bacteria by specialized transduction – an event that may increase bacterial virulence, for example, by promoting antibiotic resistance. Now, advances in sequencing technologies and synthetic biology are providing new opportunities to explore the use of temperate phages for therapy against bacterial infections. By doing so we can considerably expand our armamentarium against the escalating threat of antibiotic-resistant bacteria.

Original languageEnglish
Pages (from-to)368-378
Number of pages11
JournalTrends in Microbiology
Volume27
Issue number4
DOIs
Publication statusPublished - 2019
Externally publishedYes

Keywords

  • antibiotic resistance
  • CRISPR-Cas
  • phage therapy
  • synthetic biology
  • temperate phages

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