Photo cleavable thioacetal block copolymers for controlled release

Yongjun Men, Tobias G. Brevé, Huanhuan Liu, Antonia G. Denkova, Rienk Eelkema*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

11 Citations (Scopus)
29 Downloads (Pure)


We present a new light cleavable polymer containing o-nitrobenzene thioacetal groups in the main chain. By conjugation to a PEG block, we synthesized block copolymers capable of forming nanoparticles in aqueous solution. We studied drug encapsulation and release using the model drug Nile Red. Irradiation with UV-A light (365 nm) leads to efficient degradation of the polymers and associated burst release of the payload. Unlike other thioacetal and thioketal polymers, these polymers are stable to reactive oxygen species (ROS), preventing non-triggered release. Moreover, the nanocarriers showed low cytotoxicity in cell viability experiments.

Original languageEnglish
Pages (from-to)3612-3618
JournalPolymer Chemistry
Issue number25
Publication statusPublished - 2021


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