TY - JOUR
T1 - Photoacoustic impulse response of lipid-coated ultrasound contrast agents
AU - Daeichin, Verya
AU - Inzunza-Ibarra, Marco A.
AU - Lum, Jordan S.
AU - Borden, Mark A.
AU - Murray, Todd W.
PY - 2021
Y1 - 2021
N2 - The utility of ultrasound imaging and therapy with microbubbles may be greatly enhanced by determining their impulse-response dynamics as a function of size and composition. Prior methods for microbubble characterization utilizing high-speed cameras, acoustic transducers and laser-based techniques typically scan a limited frequency range. Here, we report on the use of a novel photoacoustic technique to measure the impulse response of single microbubbles. Individual microbubbles are driven with a broadband photoacoustic wave generated by a nanosecond-pulse laser illuminating an optical absorber. The resulting microbubble oscillations were detected by following transmission of a second laser as it passes twice through the microbubble. The system could even resolve oscillations resulting from a single-shot. As a proof-of-concept study, the size-dependent, linear impulse response of lipid-coated microbubbles was characterized using this technique. This unique method of microbubble characterization with exceptional spatiotemporal resolution opens new avenues for capturing and analyzing microbubble system dynamics.
AB - The utility of ultrasound imaging and therapy with microbubbles may be greatly enhanced by determining their impulse-response dynamics as a function of size and composition. Prior methods for microbubble characterization utilizing high-speed cameras, acoustic transducers and laser-based techniques typically scan a limited frequency range. Here, we report on the use of a novel photoacoustic technique to measure the impulse response of single microbubbles. Individual microbubbles are driven with a broadband photoacoustic wave generated by a nanosecond-pulse laser illuminating an optical absorber. The resulting microbubble oscillations were detected by following transmission of a second laser as it passes twice through the microbubble. The system could even resolve oscillations resulting from a single-shot. As a proof-of-concept study, the size-dependent, linear impulse response of lipid-coated microbubbles was characterized using this technique. This unique method of microbubble characterization with exceptional spatiotemporal resolution opens new avenues for capturing and analyzing microbubble system dynamics.
KW - Laser-ultrasonics
KW - nondestructive testing
KW - photoacoustics
KW - ultrasound contrast agents
UR - http://www.scopus.com/inward/record.url?scp=85099722934&partnerID=8YFLogxK
U2 - 10.1109/TUFFC.2021.3052140
DO - 10.1109/TUFFC.2021.3052140
M3 - Article
AN - SCOPUS:85099722934
SN - 0885-3010
VL - 68
SP - 2311
EP - 2314
JO - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
JF - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
IS - 6
M1 - 9326331
ER -