Photoacoustic impulse response of lipid-coated ultrasound contrast agents

Verya Daeichin, Marco A. Inzunza-Ibarra, Jordan S. Lum, Mark A. Borden, Todd W. Murray

Research output: Contribution to journalArticleScientificpeer-review

Abstract

The utility of ultrasound imaging and therapy with microbubbles may be greatly enhanced by determining their impulse-response dynamics as a function of size and composition. Prior methods for microbubble characterization utilizing high-speed cameras, acoustic transducers and laser-based techniques typically scan a limited frequency range. Here, we report on the use of a novel photoacoustic technique to measure the impulse response of single microbubbles. Individual microbubbles are driven with a broadband photoacoustic wave generated by a nanosecond-pulse laser illuminating an optical absorber. The resulting microbubble oscillations were detected by following transmission of a second laser as it passes twice through the microbubble. The system could even resolve oscillations resulting from a single-shot. As a proof-of-concept study, the size-dependent, linear impulse response of lipid-coated microbubbles was characterized using this technique. This unique method of microbubble characterization with exceptional spatiotemporal resolution opens new avenues for capturing and analyzing microbubble system dynamics.

Original languageEnglish
Article number9326331
Pages (from-to)2311-2314
JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Volume68
Issue number6
DOIs
Publication statusPublished - 2021

Keywords

  • Laser-ultrasonics
  • nondestructive testing
  • photoacoustics
  • ultrasound contrast agents

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