Polar Mapper is a computational application for exposing the architecture of protein interaction networks. It facilitates the system-level analysis of mRNA expression data in the context of the underlying protein interaction network. Preliminary analysis of a human protein interaction network and comparison of the yeast oxidative stress and heat shock gene expression responses are addressed as case studies.
- protein interaction network
- functional genomics
- systems biology
Goncalves, J. P., Grãos, M., & Valente, A. X. C. N. (2009). POLAR MAPPER: A computational tool for integrated visualization of protein interaction networks and mRNA expression data. Journal of the Royal Society Interface, 6(39), 881-896. https://doi.org/10.1098/rsif.2008.0407