TY - JOUR
T1 - Potential-Dependent Stochastic Amperometry of Multiferrocenylthiophenes in an Electrochemical Nanogap Transducer
AU - Mathwig, Klaus
AU - Zafarani, Hamid R.
AU - Speck, J. Matthäus
AU - Sarkar, Sahana
AU - Lang, Heinrich
AU - Lemay, Serge G.
AU - Rassaei, Liza
AU - Schmidt, Oliver G.
PY - 2016
Y1 - 2016
N2 - In nanofluidic electrochemical sensors based on redox cycling, zeptomole quantities of analyte molecules can be detected as redox-active molecules travel diffusively between two electrodes separated by a nanoscale gap. These sensors are employed to study the properties of multiferrocenylic compounds in nonpolar media, 2,3,4-triferrocenylthiophene and 2,5-diferrocenylthiophene, which display well-resolved electrochemically reversible one-electron transfer processes. Using stochastic analysis, we are able to determine, as a function of the oxidation states of a specific redox couple, the effective diffusion coefficient as well as the faradaic current generated per molecule, all in a straightforward experiment requiring only a mesoscopic amount of molecules in a femtoliter compartment. It was found that diffusive transport is reduced for higher oxidation states and that analytes yield very high currents per molecule of 15 fA.
AB - In nanofluidic electrochemical sensors based on redox cycling, zeptomole quantities of analyte molecules can be detected as redox-active molecules travel diffusively between two electrodes separated by a nanoscale gap. These sensors are employed to study the properties of multiferrocenylic compounds in nonpolar media, 2,3,4-triferrocenylthiophene and 2,5-diferrocenylthiophene, which display well-resolved electrochemically reversible one-electron transfer processes. Using stochastic analysis, we are able to determine, as a function of the oxidation states of a specific redox couple, the effective diffusion coefficient as well as the faradaic current generated per molecule, all in a straightforward experiment requiring only a mesoscopic amount of molecules in a femtoliter compartment. It was found that diffusive transport is reduced for higher oxidation states and that analytes yield very high currents per molecule of 15 fA.
UR - http://www.scopus.com/inward/record.url?scp=84991689340&partnerID=8YFLogxK
U2 - 10.1021/acs.jpcc.6b07320
DO - 10.1021/acs.jpcc.6b07320
M3 - Article
AN - SCOPUS:84991689340
SN - 1932-7447
VL - 120
SP - 23262
EP - 23267
JO - The Journal of Physical Chemistry C
JF - The Journal of Physical Chemistry C
IS - 40
ER -