Practical differentiation using ultrasensitive molecular circuits

Christian Cuba Samaniego, Giulia Giordano, Elisa Franco

Research output: Chapter in Book/Conference proceedings/Edited volumeConference contributionScientificpeer-review

6 Citations (Scopus)
135 Downloads (Pure)


Biological systems compute spatial and temporal gradients with a variety of mechanisms, some of which have been shown to include integral feedback. In traditional engineering fields, it is well known that integral components within a negative feedback loop can be used to perform a derivative action. In this paper, we define the concept of a practical differentiator that is inspired by this design principle. We then consider three simple biological circuit examples in which we prove that feedback combined with ultrasensitive, quasi-integral components yields a practical differential network under some assumptions. These examples include phosphory-lation/dephosphorylation cycles, and two networks relying on molecular sequestration.
Original languageEnglish
Title of host publicationProceedings of the 18th European Control Conference (ECC 2019)
Place of PublicationPisacataway, NJ, USA
ISBN (Electronic)978-3-907144-00-8
Publication statusPublished - 2019
EventECC 2019: 18th European Control Conference - Napoli, Italy
Duration: 25 Jun 201928 Jun 2019


ConferenceECC 2019: 18th European Control Conference

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