Predicting symptomatic mesenteric mass in small intestinal neuroendocrine tumors using radiomics

Anela Blazevic, Martijn P.A. Starmans, Tessa Brabander, Roy S. Dwarkasing, Renza A.H. van Gils, Johannes Hofland, Gaston J.H. Franssen, Wiro J. Niessen, Stefan Klein, More Authors

Research output: Contribution to journalArticleScientificpeer-review

4 Citations (Scopus)


Metastatic mesenteric masses of small intestinal neuroendocrine tumors (SI-NETs) are known to often cause intestinal complications. The aim of this study was to identify patients at risk to develop these complications based on routinely acquired CT scans using a standardized set of clinical criteria and radiomics. Retrospectively, CT scans of SI-NET patients with a mesenteric mass were included and systematically evaluated by five clinicians. For the radiomics approach, 1128 features were extracted from segmentations of the mesenteric mass and mesentery, after which radiomics models were created using a combination of machine learning approaches. The performances were compared to a multidisciplinary tumor board (MTB). The dataset included 68 patients (32 asymptomatic, 36 symptomatic). The clinicians had AUCs between 0.62 and 0.85 and showed poor agreement. The best radiomics model had a mean AUC of 0.77. The MTB had a sensitivity of 0.64 and specificity of 0.68. We conclude that systematic clinical evaluation of SI-NETs to predict intestinal complications had a similar performance than an expert MTB, but poor inter-observer agreement. Radiomics showed a similar performance and is objective, and thus is a promising tool to correctly identify these patients. However, further validation is needed before the transition to clinical practice.

Original languageEnglish
Pages (from-to)529-539
JournalEndocrine-related cancer
Issue number8
Publication statusPublished - 2021


  • carcinoid
  • computed tomography
  • gastroenteropancreatic neuroendocrine tumors
  • imaging
  • mesenteric fibrosis
  • mesenteric mass
  • neuroendocrine tumor
  • radiomics
  • small intestine
  • surgery


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