Prospects and challenges for graphene drums as sensors of individual bacteria

I. E. Rosłoń; A. Japaridze; L. Naarden; L. Smeets; C. Dekker; A. van Belkum; P. G. Steeneken; F. Alijani

doi:10.1063/5.0186160

Prospects and challenges for graphene drums as sensors of individual bacteria

I. E. Rosłoń, A. Japaridze, L. Naarden, L. Smeets, C. Dekker, A. van Belkum, P. G. Steeneken, F. Alijani^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

Abstract

Graphene-drum-enabled nanomotion detection can play an important role in probing life at the nanoscale. By combining micro- and nanomechanical systems with optics, nanomotion sensors bridge the gap between mechanics and cellular biophysics. They have allowed investigation of processes involved in metabolism, growth, and structural organization of a large variety of microorganisms, ranging from yeasts to bacterial cells. Using graphene drums, these processes can now be resolved at the single-cell level. In this Perspective, we discuss the key achievements of nanomotion spectroscopy and peek forward into the prospects for application of this single-cell technology in clinical settings. Furthermore, we discuss the steps required for implementation and look into applications beyond microbial sensing.

Original language	English
Article number	010501
Journal	Applied Physics Letters
Volume	124
Issue number	1
DOIs	https://doi.org/10.1063/5.0186160
Publication status	Published - 2024

Funding

The financial support was provided from the European Union's Horizon 2020 research and innovation programme under ERC starting grant ENIGMA (No. 802093, F.A. and I.E.R.), ERC PoC GRAPHFITI (No. 966720, F.A. and A.J.), Dutch Research Council (NWO) take-off grant, and Graphene Flagship (Grant Nos. 785219 and 881603, P.G.S.). We also acknowledge the financial support from European Innovation Council Transition Grant (No. 101136371, I.E.R, A.J., P.G.S., and F.A.) as well as UNIIQ: Finance the Future and Graduate Entrepreneur Fund.

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abstract = "Graphene-drum-enabled nanomotion detection can play an important role in probing life at the nanoscale. By combining micro- and nanomechanical systems with optics, nanomotion sensors bridge the gap between mechanics and cellular biophysics. They have allowed investigation of processes involved in metabolism, growth, and structural organization of a large variety of microorganisms, ranging from yeasts to bacterial cells. Using graphene drums, these processes can now be resolved at the single-cell level. In this Perspective, we discuss the key achievements of nanomotion spectroscopy and peek forward into the prospects for application of this single-cell technology in clinical settings. Furthermore, we discuss the steps required for implementation and look into applications beyond microbial sensing.",

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AU - Rosłoń, I. E.

AU - Japaridze, A.

AU - Naarden, L.

AU - Smeets, L.

AU - Dekker, C.

AU - van Belkum, A.

AU - Steeneken, P. G.

AU - Alijani, F.

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AB - Graphene-drum-enabled nanomotion detection can play an important role in probing life at the nanoscale. By combining micro- and nanomechanical systems with optics, nanomotion sensors bridge the gap between mechanics and cellular biophysics. They have allowed investigation of processes involved in metabolism, growth, and structural organization of a large variety of microorganisms, ranging from yeasts to bacterial cells. Using graphene drums, these processes can now be resolved at the single-cell level. In this Perspective, we discuss the key achievements of nanomotion spectroscopy and peek forward into the prospects for application of this single-cell technology in clinical settings. Furthermore, we discuss the steps required for implementation and look into applications beyond microbial sensing.

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Prospects and challenges for graphene drums as sensors of individual bacteria

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