Proteomic Reference Map and Comparative Analysis between Streptomyces griseus S4-7 and wbiE2 Transcription Factor-Mutant Strain

Jisu Kim, Young Sang Kwon, Dong-Won Bae, Youn-Sig Kwak

Research output: Contribution to journalArticleScientificpeer-review


Streptomyces griseus S4-7, a well-characterized key- stone taxon among strawberry microbial communi- ties, shows exceptional disease-preventing ability. The whole-genome sequence, functional genes, and bioactive secondary metabolites of the strain have been described in previous studies. However, proteomics studies of not only the S4-7 strain, but also the Streptomyces genus as a whole, remain limited to date. Therefore, in the pres- ent study, we created a proteomics reference
map for S. griseus S4-7. Additionally, analysis of differentially expressed proteins was performed against a wblE2 mu- tant, which was deficient in spore chain development and did not express an antifungal activity-regulatory transcription factor. We believe that our data provide a foundation for further in-depth studies of functional keystone taxa of the phytobiome and elucidation of the mechanisms underlying plant-microbe interactions, especially those involving the Streptomyces genus.

Original languageEnglish
Pages (from-to)185-191
Issue number2
Publication statusPublished - Apr 2020
Externally publishedYes


  • antifungal microbe
  • keystone taxa
  • secondary metabolite
  • spore formation
  • whi-type transcription factor

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