Quantum Sensing and Fabrication of Color Centers in Diamond: Toward a Quantum Biosensor based on CMOS-integrated NV Centers

This dissertation presents advancements toward the development of a compact quantum biosensor by integrating nitrogen-vacancy (NV) centers in diamond with CMOS-fabricated Single-Photon Avalanche Diode (SPAD) arrays. It combines efforts across various research domains and includes simulations, design, and experimental work, in order to tackle challenges in quantumsensing, imaging, fabrication, and device integration.
A custom confocal Optically Detected Magnetic Resonance (ODMR) setup was designed and employed to study magnetic properties in biosamples. HEK293T cells cultured on diamond substrates were tagged with superparamagnetic nanoparticles to act as magnetic probes. Measurements included photoluminescence (PL) mapping and 2D ODMR scans. Although the weak magnetization of the nanoparticles limited magnetic field detection, it still proved the feasibility of such a bio-imaging method and highlighted areas for improvement....