Radiation resistant metal–organic frameworks for the production of high specific activity 51Cr by the Szilard-Chalmers effect

Chao Ma, Iván Sánchez-García, Runze Wang, Hitos Galán, Antonia G. Denkova, Pablo Serra Crespo*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Chromium-51 (51Cr) is an attractive radionuclide for diagnosis, which is usually applied for red cells and platelet radiolabeling. However, commercially available 51Cr produced in nuclear reactors via neutron activation requires long irradiation times and complex separation methods. In this work, five metal–organic frameworks (MIL-100 (Cr), MIL-100 (Fe), MIL-100 (Al), MIL-101 (Cr) and aluminium fumarate MOF (FuAl)) were synthesized and the effect of gamma ray irradiation with a high dose rate and a maximum dose of 6 MGy was investigated. The two chromium-based MOFs, MIL-100 (Cr) and MIL-101 (Cr), were selected as radiation targets to produce high specific activity 51Cr by the Szilard-Chalmers effect. A solid–liquid extraction was applied to extract the produced 51Cr under different conditions, including different extractants, extraction times and pH. The most promising results were achieved when using irradiated MIL-101 (Cr) and EDTA as extracting agent, reaching an enrichment factor of 1132 ± 50.
Original languageEnglish
Article number128212
Number of pages7
JournalSeparation and Purification Technology
Volume352
DOIs
Publication statusPublished - 2025

Keywords

  • 51Cr
  • Gamma Rays
  • Metal-Organic Frameworks
  • Radiation Stability
  • Szilard-Chalmers Effect

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