TY - JOUR
T1 - Radiation resistant metal–organic frameworks for the production of high specific activity 51Cr by the Szilard-Chalmers effect
AU - Ma, Chao
AU - Sánchez-García, Iván
AU - Wang, Runze
AU - Galán, Hitos
AU - Denkova, Antonia G.
AU - Serra Crespo, Pablo
N1 - .
PY - 2025
Y1 - 2025
N2 - Chromium-51 (51Cr) is an attractive radionuclide for diagnosis, which is usually applied for red cells and platelet radiolabeling. However, commercially available 51Cr produced in nuclear reactors via neutron activation requires long irradiation times and complex separation methods. In this work, five metal–organic frameworks (MIL-100 (Cr), MIL-100 (Fe), MIL-100 (Al), MIL-101 (Cr) and aluminium fumarate MOF (FuAl)) were synthesized and the effect of gamma ray irradiation with a high dose rate and a maximum dose of 6 MGy was investigated. The two chromium-based MOFs, MIL-100 (Cr) and MIL-101 (Cr), were selected as radiation targets to produce high specific activity 51Cr by the Szilard-Chalmers effect. A solid–liquid extraction was applied to extract the produced 51Cr under different conditions, including different extractants, extraction times and pH. The most promising results were achieved when using irradiated MIL-101 (Cr) and EDTA as extracting agent, reaching an enrichment factor of 1132 ± 50.
AB - Chromium-51 (51Cr) is an attractive radionuclide for diagnosis, which is usually applied for red cells and platelet radiolabeling. However, commercially available 51Cr produced in nuclear reactors via neutron activation requires long irradiation times and complex separation methods. In this work, five metal–organic frameworks (MIL-100 (Cr), MIL-100 (Fe), MIL-100 (Al), MIL-101 (Cr) and aluminium fumarate MOF (FuAl)) were synthesized and the effect of gamma ray irradiation with a high dose rate and a maximum dose of 6 MGy was investigated. The two chromium-based MOFs, MIL-100 (Cr) and MIL-101 (Cr), were selected as radiation targets to produce high specific activity 51Cr by the Szilard-Chalmers effect. A solid–liquid extraction was applied to extract the produced 51Cr under different conditions, including different extractants, extraction times and pH. The most promising results were achieved when using irradiated MIL-101 (Cr) and EDTA as extracting agent, reaching an enrichment factor of 1132 ± 50.
KW - 51Cr
KW - Gamma Rays
KW - Metal-Organic Frameworks
KW - Radiation Stability
KW - Szilard-Chalmers Effect
UR - http://www.scopus.com/inward/record.url?scp=85194771660&partnerID=8YFLogxK
U2 - 10.1016/j.seppur.2024.128212
DO - 10.1016/j.seppur.2024.128212
M3 - Article
AN - SCOPUS:85194771660
SN - 1383-5866
VL - 352
JO - Separation and Purification Technology
JF - Separation and Purification Technology
M1 - 128212
ER -