Radiofrequency Pulse Design for Robust Quantitative Spin-Lock MRI

Research output: ThesisDissertation (TU Delft)

73 Downloads (Pure)

Abstract

Magnetic resonance imaging (MRI) is one of the most powerful tools currently available for diagnostic imaging and medical research. MRI can provide information about the composition, structure, and function of biological tissues and systems in a non-invasive way, with unsurpassed soft-tissue contrast and spatial resolution. While MRI images typically depict qualitative information, quantitative MRI techniques have emerged for their promise of enabling objective and intra-and inter-subject comparable quantification of tissue properties. Quantitative MRI techniques yield parametric maps, which are voxel-wise representations of physical properties of tissues, such as relaxation times. MRI relaxation times, conventionally T1 and T2, characterize the evolution of the excited MRI signal back to its equilibrium value and they are directly influenced by the molecular environment. Thus, T1 and T2 parametric maps yield useful insight into the normal state of biological tissues and eventual pathological remodeling.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Delft University of Technology
Supervisors/Advisors
  • Vos, F.M., Supervisor
  • Weingärtner, S.D., Advisor
Award date27 Sept 2024
Electronic ISBNs978-94-6384-636-3
DOIs
Publication statusPublished - 2024

Keywords

  • quantitative MRI
  • spin-lock relaxation
  • rotating-frame of reference
  • adiabatic RF
  • T1ρ mapping
  • T2ρ mapping

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