Real-Time Monitoring of Size and Concentration of Nanoparticles Inside a Reactor Using Ultrasound

G. J.A. Van Groenestijn, N. M.M. Meulendiiks, A. W.F. Volker, P. L.M.J. Van Neer, P. J.P. Buskens

    Research output: Chapter in Book/Conference proceedings/Edited volumeConference contributionScientificpeer-review

    1 Citation (Scopus)


    Nanoparticles are applied in an increasing number of products (e.g. medicine, food and cosmetics). There is a need to real-time monitor the growth of nanoparticles during production inside the chemical reactor. However, standard particle sizing methods such as dynamic light scattering (DLS) and transmission electron microscopy (TEM) cannot do this. A suitable candidate may be ultrasonic transmission spectroscopy (UTS). Here, the sound speed and attenuation are measured of a dispersion and a physics based model is inverted and fitted to the measurements. The measurements have to be done with great accuracy: e.g. one should be able to measure frequency dependent variations in the speed of sound smaller than 0.05%. The measurements also have to be carried out fast enough compared to the time scale of the reaction. Moreover, the inversion has to be able to deal with the changing properties of the solvent during particle formation. Here, we report on the new ultrasound nanoparticle sizer (UNPS) that has these abilities and therefore could successfully monitor the size and concentration growth of nanoparticles during a reaction inside a reactor in real-time.

    Original languageEnglish
    Title of host publication2018 IEEE International Ultrasonics Symposium, IUS 2018
    EditorsKen-ya Hashimoto , Clemens Ruppel
    Number of pages4
    ISBN (Electronic)978-153863425-7
    Publication statusPublished - 2018
    Event2018 IEEE International Ultrasonics Symposium, IUS 2018 - Portopia Hotel, Kobe, Japan
    Duration: 22 Oct 201825 Oct 2018


    Conference2018 IEEE International Ultrasonics Symposium, IUS 2018
    Abbreviated titleIUS 2018


    • colloids
    • nanoparticle size and concentration
    • nanoparticle synthesis
    • realtime analysis
    • Stöber reaction
    • sub-micron particles size and concentration
    • ultrasound spectroscopy


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