TY - JOUR
T1 - Real-time photoacoustic assessment of radiofrequency ablation lesion formation in the left atrium
AU - Iskander-Rizk, Sophinese
AU - Kruizinga, Pieter
AU - Beurskens, Robert
AU - Springeling, Geert
AU - Mastik, Frits
AU - de Groot, Natasja M.S.
AU - Knops, Paul
AU - van der Steen, Antonius F.W.
AU - van Soest, Gijs
PY - 2019
Y1 - 2019
N2 - In interventional electrophysiology, catheter-based radiofrequency (RF) ablation procedures restore cardiac heart rhythm by interrupting aberrant conduction paths. Real-time feedback on lesion formation and post-treatment lesion assessment could overcome procedural challenges related to ablation of underlying structures and lesion gaps. This study aims to evaluate real-time visualization of lesion progression and continuity during intra-atrial ablation with photoacoustic (PA) imaging, using clinically deployable technology. A PA-enabled RF ablation catheter was used to ablate and illuminate porcine left atrium, both excised and intact in a passive beating heart ex-vivo, for photoacoustic signal generation. PA signals were received with an intracardiac echography catheter. Using the ratio of PA images acquired with excitation wavelengths of 790 nm and 930 nm, ablation lesions were successfully imaged through circulating saline and/or blood, and lesion gaps were identified in real-time. PA-based assessment of RF-ablation lesions was successful in a realistic preclinical model of atrial intervention.
AB - In interventional electrophysiology, catheter-based radiofrequency (RF) ablation procedures restore cardiac heart rhythm by interrupting aberrant conduction paths. Real-time feedback on lesion formation and post-treatment lesion assessment could overcome procedural challenges related to ablation of underlying structures and lesion gaps. This study aims to evaluate real-time visualization of lesion progression and continuity during intra-atrial ablation with photoacoustic (PA) imaging, using clinically deployable technology. A PA-enabled RF ablation catheter was used to ablate and illuminate porcine left atrium, both excised and intact in a passive beating heart ex-vivo, for photoacoustic signal generation. PA signals were received with an intracardiac echography catheter. Using the ratio of PA images acquired with excitation wavelengths of 790 nm and 930 nm, ablation lesions were successfully imaged through circulating saline and/or blood, and lesion gaps were identified in real-time. PA-based assessment of RF-ablation lesions was successful in a realistic preclinical model of atrial intervention.
KW - Atrial fibrillation
KW - Lesion monitoring
KW - Photoacoustic imaging
KW - Photoacoustic-enabled RF ablation catheter
KW - RF ablation
UR - http://www.scopus.com/inward/record.url?scp=85076060642&partnerID=8YFLogxK
U2 - 10.1016/j.pacs.2019.100150
DO - 10.1016/j.pacs.2019.100150
M3 - Article
AN - SCOPUS:85076060642
SN - 2213-5979
VL - 16
JO - Photoacoustics
JF - Photoacoustics
M1 - 100150
ER -