Real-time volumetric lipid imaging in vivo by intravascular photoacoustics at 20 frames per second

Min Wu, Geert Springeling, Matija Lovrak, Frits Mastik, Sophinese Iskander-Rizk, Tianshi Wang, Heleen M.M. Van Beusekom, A. F.W. Van Der Steen, Gijs Van Soest

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Abstract

Lipid deposition can be assessed with combined intravascular photoacoustic/ultrasound (IVPA/US) imaging. To date, the clinical translation of IVPA/US imaging has been stalled by a low imaging speed and catheter complexity. In this paper, we demonstrate imaging of lipid targets in swine coronary arteries in vivo, at a clinically useful frame rate of 20 s−1. We confirmed image contrast for atherosclerotic plaque in human samples ex vivo. The system is on a mobile platform and provides real-time data visualization during acquisition. We achieved an IVPA signal-to-noise ratio of 20 dB. These data show that clinical translation of IVPA is possible in principle.

Original languageEnglish
Article number#282694
Pages (from-to)943-953
Number of pages11
JournalBiomedical Optics Express
Volume8
Issue number2
DOIs
Publication statusPublished - 1 Feb 2017

Keywords

  • Imaging systems
  • Photoacoustic imaging

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    Wu, M., Springeling, G., Lovrak, M., Mastik, F., Iskander-Rizk, S., Wang, T., Van Beusekom, H. M. M., Van Der Steen, A. F. W., & Van Soest, G. (2017). Real-time volumetric lipid imaging in vivo by intravascular photoacoustics at 20 frames per second. Biomedical Optics Express, 8(2), 943-953. [#282694]. https://doi.org/10.1364/BOE.8.000943