Real-time volumetric lipid imaging in vivo by intravascular photoacoustics at 20 frames per second

Min Wu; Geert Springeling; Matija Lovrak; Frits Mastik; Sophinese Iskander-Rizk; Tianshi Wang; Heleen M.M. Van Beusekom; A. F.W. Van Der Steen; Gijs Van Soest

doi:10.1364/BOE.8.000943

Real-time volumetric lipid imaging in vivo by intravascular photoacoustics at 20 frames per second

Min Wu, Geert Springeling, Matija Lovrak, Frits Mastik, Sophinese Iskander-Rizk, Tianshi Wang, Heleen M.M. Van Beusekom, A. F.W. Van Der Steen, Gijs Van Soest

ChemE/Advanced Soft Matter

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Abstract

Lipid deposition can be assessed with combined intravascular photoacoustic/ultrasound (IVPA/US) imaging. To date, the clinical translation of IVPA/US imaging has been stalled by a low imaging speed and catheter complexity. In this paper, we demonstrate imaging of lipid targets in swine coronary arteries in vivo, at a clinically useful frame rate of 20 s⁻¹. We confirmed image contrast for atherosclerotic plaque in human samples ex vivo. The system is on a mobile platform and provides real-time data visualization during acquisition. We achieved an IVPA signal-to-noise ratio of 20 dB. These data show that clinical translation of IVPA is possible in principle.

Original language	English
Article number	#282694
Pages (from-to)	943-953
Number of pages	11
Journal	Biomedical Optics Express
Volume	8
Issue number	2
DOIs	https://doi.org/10.1364/BOE.8.000943
Publication status	Published - 1 Feb 2017

Keywords

Imaging systems
Photoacoustic imaging

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AU - Springeling, Geert

AU - Lovrak, Matija

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AU - Iskander-Rizk, Sophinese

AU - Wang, Tianshi

AU - Van Beusekom, Heleen M.M.

AU - Van Der Steen, A. F.W.

AU - Van Soest, Gijs

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Real-time volumetric lipid imaging in vivo by intravascular photoacoustics at 20 frames per second

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Keywords

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