TY - JOUR
T1 - Recent trends in synthetic enzymatic cascades promoted by alcohol dehydrogenases
AU - de Gonzalo, Gonzalo
AU - Paul, Caroline E.
PY - 2021
Y1 - 2021
N2 - Alcohol dehydrogenases have fascinated chemists over the span of a few decades to catalyze oxidation and reduction reactions and have been increasingly incorporated as biocatalysts in scaled-up industrial processes for the production of valuable chiral compounds under mild and environmentally friendly conditions. In this review, we discuss recent advances on alcohol dehydrogenases coupled in cascade reactions with other enzyme classes, chemocatalysts, or organocatalysts to obtain high value–added products. The examples include deracemization processes for the synthesis of chiral diols and amino alcohols, whole-cell and co-expression systems, and chemoenzymatic and organoenzymatic cascades, with a vision for future developments.
AB - Alcohol dehydrogenases have fascinated chemists over the span of a few decades to catalyze oxidation and reduction reactions and have been increasingly incorporated as biocatalysts in scaled-up industrial processes for the production of valuable chiral compounds under mild and environmentally friendly conditions. In this review, we discuss recent advances on alcohol dehydrogenases coupled in cascade reactions with other enzyme classes, chemocatalysts, or organocatalysts to obtain high value–added products. The examples include deracemization processes for the synthesis of chiral diols and amino alcohols, whole-cell and co-expression systems, and chemoenzymatic and organoenzymatic cascades, with a vision for future developments.
UR - http://www.scopus.com/inward/record.url?scp=85116454633&partnerID=8YFLogxK
U2 - 10.1016/j.cogsc.2021.100548
DO - 10.1016/j.cogsc.2021.100548
M3 - Review article
AN - SCOPUS:85116454633
SN - 2452-2236
VL - 32
JO - Current Opinion in Green and Sustainable Chemistry
JF - Current Opinion in Green and Sustainable Chemistry
M1 - 100548
ER -