Reliability of rapid TMS stimulus-response curves during Tibialis Anterior contractions on healthy elderly

E. Peri, V.M. Colombo, E. Ambrosini, M. van de Ruit, M.J. Grey, M. Monticone, A. Pedrocchi, G. Ferrigno, S. Ferrante

Research output: Chapter in Book/Conference proceedings/Edited volumeConference contributionScientificpeer-review

2 Citations (Scopus)

Abstract

Transcranial Magnetic Stimulation (TMS) is a widespread technique to study corticospinal excitability. Its use in longitudinal studies is crucial to analyze the plasticity induced by rehabilitation treatments on neuromotor-impaired subjects. As TMS-related measures fluctuate with time and attention, it is crucial to collect them rapidly. Recently, it has been shown that stimulus-response (SR) curves can be acquired in less than two minutes (Mathias et al.). This technique favors the clinical use of TMS-related measures, but its intersession reliability has not been investigated yet. In this study we propose a test-retest reliability analysis of five parameters extracted from SR curves acquired on the preactivated Tibialis Anterior (TA) using the fast acquisition method. A secondary aim was to compare the reliability of these parameters for two different calculation methods of the Motor Evoked Potential (MEP) amplitude: the peak-to-peak value, referred as MEPpp, and the root mean square value, referred as MEParea. The intraclass correlation coefficients (ICC), the standard error of measurement (SEM) and the minimum detectable changes (MDC) were evaluated. Thirteen neurologically-intact elders (age 62.2±5.1) were recruited. The acquisition protocol was set up to minimize the variability of the measurement between the two sessions, carried out on separate days: an optical tracking system was used to maintain the coil placement, the EMG data were normalized over the maximum peripherally evoked action potential and a visual feedback was displayed to the testing subject to maintain the TA activation level. All the parameters, regardless the method used to compute the MEP amplitude , showed good to excellent reliability (0.75

Original languageEnglish
Title of host publicationIFMBE Proceedings - XIV Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2016
Subtitle of host publicationIFMBE Proceedings
EditorsE. Kyriacou, S. Christofides, C.S. Pattichis
Place of PublicationCham, Switzerland
PublisherSpringer
Pages1075-1080
Volume57
ISBN (Electronic)978-3-319-32703-7
ISBN (Print)978-3-319-32701-3
DOIs
Publication statusPublished - 2016
Event14th Mediterranean Conference on Medical and Biological Engineering and Computing - Paphos, Cyprus
Duration: 31 Mar 20162 Apr 2016
Conference number: 14th

Conference

Conference14th Mediterranean Conference on Medical and Biological Engineering and Computing
Abbreviated titleMEDICON 2016
CountryCyprus
CityPaphos
Period31/03/162/04/16

Keywords

  • Elderly
  • Healthy subjects
  • Inter-session reliability
  • Stimulus-response curve
  • Transcranial magnetic stimulation

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