Rolling-Horizon Simulation Optimization For A Multi-Objective Biomanufacturing Scheduling Problem

Kim Van Den Houten*, Mathijs De Weerdt, David M.J. Tax, Esteban Freydell, Eva Christoupoulou, Alessandro Nati

*Corresponding author for this work

Research output: Chapter in Book/Conference proceedings/Edited volumeConference contributionScientificpeer-review


We study a highly complex scheduling problem that requires the generation and optimization of production schedules for a multi-product biomanufacturing system with continuous and batch processes. There are two main objectives here; makespan and lateness, which are combined into a cost function that is a weighted sum. An additional complexity comes from long horizons considered (up to a full year), yielding problem instances with more than 200 jobs, each consisting of multiple tasks that must be executed in the factory. We investigate whether a rolling-horizon principle is more efficient than a global strategy. We evaluate how cost function weights for makespan and lateness should be set in a rolling-horizon approach where deadlines are used for subproblem definition. We show that the rolling-horizon strategy outperforms a global search, evaluated on problem instances of a real biomanufacturing system, and we show that this result generalizes to problem instances of a synthetic factory.

Original languageEnglish
Title of host publicationProceedings of the 2023 Winter Simulation Conference (WSC)
Number of pages12
ISBN (Electronic)979-8-3503-6966-3
ISBN (Print)979-8-3503-6967-0
Publication statusPublished - 2023
Event2023 Winter Simulation Conference, WSC 2023 - San Antonio, United States
Duration: 10 Dec 202313 Dec 2023

Publication series

NameProceedings - Winter Simulation Conference
ISSN (Print)0891-7736


Conference2023 Winter Simulation Conference, WSC 2023
Country/TerritoryUnited States
CitySan Antonio

Bibliographical note

Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project
Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.


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