Development of natural resources in harsh environments presents significant technical and logistical challenges. An industrial workshop on "safety and integrity management of operations in harsh environments" was organized by the safety and risk engineering group at Memorial University to bring together industrial practitioners, regulatory authorities, and research and development institutions to identify the safety and integrity challenges in harsh environments, share experience and develop a roadmap for desired solutions. This article summarizes the lessons learned from the workshop on safety issues in harsh environments. The workshop identified that there are safety challenges regarding construction and operation including a lack of detailed standards, optimization with respect to winterization, and data scarcity. The remoteness of operations in harsh environments is an additional challenge. Finally, the human factors add another set of challenges that arise from the physical and psychological behavior of plant personnel in harsh and remote environments.