Selective Crystallization of d-Mannitol Polymorphs Using Surfactant Self-Assembly

F. Marques Penha, A. Gopalan, J.C. Meijlink, F. Ibis, H.B. Eral

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)
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Selective crystallization of polymorphs is highly sought after in industrial practice. Yet, state-of-the-art techniques either use laboriously engineered solid surfaces or strenuously prepared heteronucleants. We propose an approach where surfactants in solution self-assemble effortlessly into mesoscopic structures dictating the polymorphic outcome of the target solute. Sodium dodecyl sulfate (SDS) surfactant is used as a tailored additive to crystallize different polymorphic forms of a model active pharmaceutical ingredient, d-mannitol. Different mesoscopic phases of SDS template particular polymorphs: packed monolayers, micelles, and crystals favored the β, α, and δ forms of d-mannitol, respectively. A synergistic effect of topological templating and molecular interactions is proposed as the rationale behind the observed selective crystallization of polymorphs. This crystal engineering technique suggests that surfactant self-assemblies can be used as tailored templates for polymorphic control.
Original languageEnglish
Pages (from-to)3928-3935
JournalCrystal Growth & Design
Issue number7
Publication statusPublished - 2021


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  • LEaDing Fellows

    Gutierrez, A., Dols Perez, A., Bae, D., Sahoo, H., Wang, W., Lam, K. L., Raimondo, A., Steffelbauer, D. B., Lesne, E. L., Ragno, E., Amador, G. J., Šiaudinyte, L., Sand, M., Robinson Garcia, N., Abil, Z., Purkarthofer, E., Noardo, F., Tasić, J. K., Marin, L., Angeloni, L., loddo, M., Stockill, R. H. J., Franklin, S. W., Hensen, B. J., Dennis, M. J., Afroza Islam, S. T., Kim, T., Manzaneque Garcia, T., Tiringer, U., Marques Penha, F., Esteban Jurado, C., Timmermans, E., McCrum, I. T., Pool, F., Forn-Cuní, G., Will, G., Barrett, H. E., Everett, J. A. C., Kostenzer, J., Luksenburg, J., Hirvasniemi, J., Desai, J., Ruibal, P., Albury, N. J., March, R., Eichengreen, A., Muok, A. R., Cochrane, A., Ravesteijn, B., Riumalló Herl, C. J., Meeusen, C., Biaggi, C., Granger, C., Cecil, C., Fosch Villaronga, E., Sánchez López, E. S., Loehrer, E., da Costa Gonçalves, F., Giardina, F., Wu, H., Gleitz, H. & Khatri, I.


    Project: Research

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