Selective Oxyfunctionalisation Reactions Driven by Sulfite Oxidase-Catalysed In Situ Generation of H2O2

Morten M.C.H. van Schie, Alexander T. Kaczmarek, Florian Tieves, Patricia Gomez de Santos, Caroline E. Paul, Isabel W.C.E. Arends, Miguel Alcalde, Günter Schwarz, Frank Hollmann

Research output: Contribution to journalArticleScientificpeer-review

3 Citations (Scopus)
38 Downloads (Pure)

Abstract

H2O2 can be accepted by several peroxygenases as a clean oxidant, able to supply both the necessary electrons and oxygen atom at the same time. The biocatalysts, in turn, are able to catalyse an array of interesting oxygen insertion reactions at enantio- and regio-selectivities hard to attain with classical chemical methods. The sensitivity of most peroxygenases towards H2O2, however, requires this oxidant to be generated in situ. Here, we suggest the application of (modified) sulfite oxidases to couple the oxidation of sulfites to the reduction of oxygen. This enables us to use calcium sulfite, an industrial waste product from scrubbing flue gases, as an electron donor to reduce oxygen. This will supply the required peroxide in a controlled manner and enables us to perform these challenging reactions at the expense of simple salts.

Original languageEnglish
Pages (from-to)3186-3189
JournalChemCatChem
Volume12
Issue number12
DOIs
Publication statusPublished - 2020

Keywords

  • Biocatalysis
  • Hydrogen peroxide
  • Oxyfunctionalisation
  • Peroxygenase
  • Sulfite oxidase

Fingerprint

Dive into the research topics of 'Selective Oxyfunctionalisation Reactions Driven by Sulfite Oxidase-Catalysed In Situ Generation of H<sub>2</sub>O<sub>2</sub>'. Together they form a unique fingerprint.

Cite this