Selective Peroxygenase-Catalysed Oxidation of Phenols to Hydroquinones

Hugo Brasselet; Fabian Schmitz; Katja Koschorreck; Vlada B. Urlacher; Frank Hollmann; Thomas Hilberath

doi:10.1002/adsc.202400872

Selective Peroxygenase-Catalysed Oxidation of Phenols to Hydroquinones

Hugo Brasselet, Fabian Schmitz, Katja Koschorreck, Vlada B. Urlacher, Frank Hollmann, Thomas Hilberath^*

^*Corresponding author for this work

BT/Biocatalysis

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Abstract

An enzymatic method for the selective hydroxylation of phenols using a peroxygenase from Aspergillus brasiliensis (AbrUPO) is reported. A broad range of phenolic starting materials can be selectively transformed into the corresponding hydroquinones. Semi-preparative syntheses of several hydroquinones were realised without further optimization pointing out the applicability of this enzyme as biocatalyst.

Original language	English
Pages (from-to)	4430-4435
Number of pages	6
Journal	Advanced Synthesis and Catalysis
Volume	366
Issue number	21
DOIs	https://doi.org/10.1002/adsc.202400872
Publication status	Published - 2024

Keywords

Biocatalysis
Hydroquinones
Oxyfunctionalisation
Peroxygenase
Phenols

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10.1002/adsc.202400872

Adv Synth Catal - 2024 - Brasselet - Selective Peroxygenase‐Catalysed Oxidation of Phenols to HydroquinonesFinal published version, 4.96 MBLicence: CC BY

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abstract = "An enzymatic method for the selective hydroxylation of phenols using a peroxygenase from Aspergillus brasiliensis (AbrUPO) is reported. A broad range of phenolic starting materials can be selectively transformed into the corresponding hydroquinones. Semi-preparative syntheses of several hydroquinones were realised without further optimization pointing out the applicability of this enzyme as biocatalyst.",

keywords = "Biocatalysis, Hydroquinones, Oxyfunctionalisation, Peroxygenase, Phenols",

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AU - Brasselet, Hugo

AU - Schmitz, Fabian

AU - Koschorreck, Katja

AU - Urlacher, Vlada B.

AU - Hollmann, Frank

AU - Hilberath, Thomas

PY - 2024

Y1 - 2024

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AB - An enzymatic method for the selective hydroxylation of phenols using a peroxygenase from Aspergillus brasiliensis (AbrUPO) is reported. A broad range of phenolic starting materials can be selectively transformed into the corresponding hydroquinones. Semi-preparative syntheses of several hydroquinones were realised without further optimization pointing out the applicability of this enzyme as biocatalyst.

KW - Biocatalysis

KW - Hydroquinones

KW - Oxyfunctionalisation

KW - Peroxygenase

KW - Phenols

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DO - 10.1002/adsc.202400872

M3 - Article

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EP - 4435

JO - Advanced Synthesis and Catalysis

JF - Advanced Synthesis and Catalysis

IS - 21

ER -

Selective Peroxygenase-Catalysed Oxidation of Phenols to Hydroquinones

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Keywords

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